Melanoma of unknown primary is correctly classified by the AJCC melanoma classification from 2009

Pfeil, Anne F., Leiter, Ulrike, Buettner, Petra G., Eigentler, Thomas K., Weide, Benjamin, Meier, Friedegund, and Garbe, Claus (2011) Melanoma of unknown primary is correctly classified by the AJCC melanoma classification from 2009. Melanoma Research, 21 (3). pp. 228-234.

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Few studies have focused on the prognosis of melanoma of unknown primary (MUP). This study aimed (i) to determine prognostic factors for patients with MUP and (ii) to investigate whether the American Joint Committee on Cancer (AJCC) 2009 classification is suitable for MUP. Among 8897 patients with melanoma attending the university department of dermatology, Tuebingen, Germany, 172 (1.9%) patients with MUP were recorded. Prognostic factors were studied using Kaplan–Meier and multivariate Cox proportional hazard models. Cutaneous and subcutaneous metastases were categorized as satellite/in-transit metastases, lymph-node metastases as regional lymph-node metastases, and all other metastases as distant metastases. Multivariate analysis found AJCC-stage at diagnosis, lactate dehydrogenase at diagnosis, number of metastases and age to be independent prognostic factors for MUP. Multivariate analyses stratified by AJCC stage showed that size of satellite/in-transit metastases (P=0.034) and number of regional lymph-node metastases (P=0.006) were significant for stage III, whereas for stage IV age (P=0.006) and lactate dehydrogenase-level at primary diagnosis (P=0.003) proved to be prognostically important. Patients with MUP can be classified according to AJCC, which presented as the strongest prognostic factor. From a management perspective it is important to notice that the majority of MUP were classified as stage III.

Item ID: 20656
Item Type: Article (Research - C1)
ISSN: 1473-5636
Keywords: AJCC 2009; melanoma of unknown primary; prognostic factors; survival analysis
Date Deposited: 06 Mar 2012 04:45
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111299 Oncology and Carcinogenesis not elsewhere classified @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 50%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920499 Public Health (excl. Specific Population Health) not elsewhere classified @ 50%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 50%
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