Opisthorchiasis and Opisthorchis-associated cholangiocarcinoma in Thailand and Laos

Sripa, Banchob, Bethony, Jeffrey, Sithithaworn, Paiboon, Kaewkes, Sasithorn, Mairiang, Eimorn, Loukas, Alex, Mulvenna, Jason, Laha, Thewarach, Hotez, Peter, and Brindley, Paul (2011) Opisthorchiasis and Opisthorchis-associated cholangiocarcinoma in Thailand and Laos. Acta Tropica, 120 (Supp 1). S158-S168.

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Abstract

Liver fluke infection caused by Opisthorchis viverrini is a major public health problem in Thailand and the Lao People's Democratic Republic (Lao PDR; Laos). Currently, more than 600 million people are at risk of infection with these fish-borne trematodes and/or their close relatives. Opisthorchiasis has been studied extensively in Thailand, where about 8 million people are infected with the liver fluke. Here we review the pathogenesis, control and re-emergence of O. viverrini infection, in particular in Thailand and, to a lesser extent in Lao PDR given the contiguous geographical range of O. viverrini through these two regions. We also review the association of O. viverrini infection and cholangiocarcinoma, bile duct cancer, and highlight new findings on pathogenesis of liver fluke-induced cholangiocarcinogenesis. Last, we comment on national control strategies in Thailand for the control of O. viverrini infection aimed at reduction in the prevalence of O. viverrini-associated liver cancer in the longer term.

Item ID: 19293
Item Type: Article (Research - C1)
ISSN: 1873-6254
Keywords: opisthorchiasis; Opisthorchis; Clonorchis; cholangiocarcinoma; liver fluke; liver cancer; food-borne trematodiases; anthelmintic; praziquantel; hepatobiliary disease
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This article is paublished under the CC-BY-NC-ND 3.0 license.

Date Deposited: 12 Dec 2011 01:38
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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