Nicholls, Phil, Squires, Richard, and Wallace, Melissa (2008) Glomerulonephritis. In: UNSPECIFIED, (ed.) Vetstream CANIS. Vetstream, UK, pp. 1-4.

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• Cause: deposition or in situ formation of antigen-antibody complexes in the basement membranes of glomerular capillaries in the kidneys.

• Signs: often no clinical signs until very advanced. Proteinuria leads to hypoalbuminemia and sometimes to subcutaneous edema, eg of the distal limbs. Severe glomerular loss may eventually lead to signs of acute or chronic renal failure, eg polydipsia/polyuria, inappetence, vomiting.

• Diagnosis: urine analysis, serum chemistry profile, histopathologic examination of a kidney biopsy.

• Treatment: detect and eliminate the underlying source of antigen, if at all possible. Special diet, low-dose aspirin, angiotensin-converting enzyme (ACE) inhibition, +/- immunosuppressant/immunomodulator therapy.

• Prognosis: very variable. Some cases progress rapidly despite therapy, others remain stable for prolonged periods. If complicated by thromboembolism (eg pulmonary or caudal aortic), prognosis is poor.

Item ID: 18748
Item Type: Book Chapter (Reference)
ISSN: 1757-8256
Additional Information:

This is a Vetstream CANIS peer reviewed journal article that was first published online in November 2008. It is updated quarterly.

Date Deposited: 27 Sep 2011 01:07
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070706 Veterinary Medicine @ 100%
SEO Codes: 86 MANUFACTURING > 8609 Veterinary Pharmaceutical Products > 860902 Veterinary Diagnostics @ 50%
86 MANUFACTURING > 8609 Veterinary Pharmaceutical Products > 860903 Veterinary Pharmaceutical Treatments (e.g. Antibiotics) @ 50%
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