Extreme neutrophilic leucocytosis and intrathoracic mass in a fox terrier

Squires, R.A., and Thompson, K.G. (2004) Extreme neutrophilic leucocytosis and intrathoracic mass in a fox terrier. New Zealand Veterinary Journal, 52 (1). p. 50.

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An 8-year-old female Fox Terrier was presented for acute anorexia and depression. A haemogram revealed extreme neutrophilic leucocytosis (136x10^9/L neutrophils). By Day 4, the neutrophilia was more marked (214x10^9/L segmented; 23x10^9/L band). Imaging revealed a cranial mediastinal mass, pleural effusion and small pneumothorax. Needle aspiration of the mass showed cells resembling malignant histiocytes against a background of mature neutrophils. On Day 7, the mass was surgically removed. Histologically, it revealed a malignancy suggestive of histiocytic sarcoma intensely infiltrated with neutrophils. Immunocytochemical investigations are pending. Post-operatively, the dog’s appetite and demeanour improved but breathing was laboured, and neutrophilia persisted (300x10^9/L on Day 14). The dog was humanely killed on Day 14; post mortem examination revealed no distant metastases. This dog's illness is strongly reminiscent of a rare human condition, inflammatory malignant fibrous histiocytoma with leukaemoid reaction (IMFH-LR). In IMFH-LR, neoplastic cells produce cytokines that attract neutrophils to the tumour. Other cytokines stimulate the bone marrow to produce extreme neutrophilia. Although paraneoplastic neutrophilia has previously been described in dogs, this is an extreme example and the condition has not previously been associated with histiocytic or intrathoracic malignancies.

Item ID: 18278
Item Type: Article (Abstract)
ISSN: 1176-0710
Date Deposited: 14 Jun 2012 04:06
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070706 Veterinary Medicine @ 100%
SEO Codes: 86 MANUFACTURING > 8609 Veterinary Pharmaceutical Products > 860902 Veterinary Diagnostics @ 50%
86 MANUFACTURING > 8609 Veterinary Pharmaceutical Products > 860903 Veterinary Pharmaceutical Treatments (e.g. Antibiotics) @ 50%
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