Antistreptokinase antibodies: implications for thrombolysis in a region with endemic streptococcal infection
Blackwell, N., Hollins, A., Gilmore, G., and Norton, R. (2005) Antistreptokinase antibodies: implications for thrombolysis in a region with endemic streptococcal infection. Journal of Clinical Pathology, 58 (9). pp. 1005-1007.
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Abstract
Aims: To determine antistreptokinase antibody (anti-SK) titres in patients with the acute coronary syndrome from communities with endemic group A streptococcal infection because of the implications for streptokinase (SK) thrombolysis.
Methods: Anti-SK titres were determined using a standard method in 47 consecutive SK naive patients, presenting to the Mt Isa Hospital emergency department, Australia, with an acute coronary syndrome. Both indigenous and non-indigenous subjects were enrolled. Antistreptolysin O (ASOT) and anti-DNAse B (ADB) titres were also determined.
Results: Indigenous patients were more likely to have anti-SK antibodies (p < 0.001) than the non-indigenous cohort. Anti-SK antibody titres also correlated well with ASOT/ADB titres.
Conclusions: Anti-SK antibodies are highly prevalent in SK naive indigenous patients presenting with the acute coronary syndrome. Streptokinase should not be used for thrombolysis in populations with endemic group A streptococcal infection.
| Item ID: | 17739 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 0021-9746 |
| Funders: | Mt Isa Centre for Rural and Remote Health |
| Date Deposited: | 04 Oct 2011 05:46 |
| FoR Codes: | 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111799 Public Health and Health Services not elsewhere classified @ 50% 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110899 Medical Microbiology not elsewhere classified @ 35% 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 15% |
| SEO Codes: | 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920404 Disease Distribution and Transmission (incl. Surveillance and Response) @ 45% 92 HEALTH > 9202 Health and Support Services > 920203 Diagnostic Methods @ 45% 92 HEALTH > 9203 Indigenous Health > 920302 Aboriginal and Torres Strait Islander Health - Health Status and Outcomes @ 10% |
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