Meta-analysis of the association between single nucleotide polymorphisms in TGF-β receptor genes and abdominal aortic aneurysm

Biros, Erik, Norman, Paul E., Jones, Gregory T., van Rij, Andre M., Yu, Grace, Moxon, Joseph V., Blankensteijn, Jan D., van Sterkenburg, Steven M., Morris, Dylan, Baas, Annette F., and Golledge, Jonathan (2011) Meta-analysis of the association between single nucleotide polymorphisms in TGF-β receptor genes and abdominal aortic aneurysm. Atherosclerosis, 219 (1). pp. 218-223.

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Abstract

Objective

The role of transforming growth factor (TGF)-beta in abdominal aortic aneurysm (AAA) is controversial. The aim of this study was to assess the association of single nucleotide polymorphisms (SNPs) within TGFBR1 and TGFBR2 with AAA and infrarenal aortic diameter by combining data from previously published studies.

Methods

We performed a meta-analysis using individual subject data from three independent case-control groups from Western Australia (n = 1675), New Zealand (n = 1209), and the Netherlands (n = 1636) with 610, 601, and 693 cases of AAA (maximum infrarenal aortic diameter ≥30 mm), respectively. Data were available for two TGFBR1 (rs10819634, rs1571590) and six TGFBR2 (rs304839, rs1346907, rs1036095, rs9831477, rs9843143, rs764522) SNPs.

Results

There was marked heterogeneity between studies. The G alleles of the TGFBR2 rs764522 and rs1036095 SNPs were associated with AAA under a recessive model (OR = 1.69, 95% CI 1.28–2.25, P < 0.001 and OR = 1.59, 95% CI 1.23–2.07, P < 0.001) when a fixed effects model was used. Both associations remained significant after adjustment for multiple testing.

Conclusion

This study suggests that two common genetic polymorphisms in TGFBR2 are associated with the risk of developing AAA although this association was mainly driven by findings in the Netherlands group and marked between study heterogeneity was detected.

Item ID: 17608
Item Type: Article (Refereed Research - C1)
Keywords: abdominal aortic aneurysm; single nucleotide polymorphism; TGFBR1; TGFBR2
ISSN: 1879-1484
Date Deposited: 03 Nov 2011 05:44
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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