Modeling the effect of selected cyclodextrins on nifedipine solubility

Agatonovic-Kustrin, Snezana, Morton, David W., Worthington, Matthew S., and Glass, Beverley D. (2011) Modeling the effect of selected cyclodextrins on nifedipine solubility. Current Drug Discovery Technologies, 8 (2). pp. 146-154.

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Nifedipine is a dihydropyridine calcium channel antagonist effective in the clinical management of cardiovascular disease. Due to nifedipine's poor water solubility and erratic bioavailability, complexation with selected cyclodextrins was studied in order to overcome these limitations. The aim was to develop a quantitative structure property relationship (QSPR) to identify cyclodextrin molecular properties important in complex formation and provide a predictive tool which would be valuable during preformulation studies. The QSPR developed indicates that the major driving forces for nifedipine complexation, in addition to cyclodextrin concentration, are hydrophobicity and Van der Waals interactions (3D solubility parameters, hydrophilic surface area and differential connectivity index).

Item ID: 17267
Item Type: Article (Research - C1)
ISSN: 1875-6220
Keywords: artificial neural networks (ANN); cyclodextrin (CD); complexation; nifedipine; phase solubility studies; quantitative structure property relationship (QSPR)
Date Deposited: 22 Jun 2011 05:57
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
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