Activation rules: the two-signal theories of immune activation

Baxter, Alan G., and Hodgkin, Philip D. (2002) Activation rules: the two-signal theories of immune activation. Nature Reviews Immunology, 2. pp. 439-446.

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Abstract

Two-signal theories of lymphocyte activation have evolved considerably over the past 35 years. In this article, we examine the contemporary experimental observations and theoretical concerns that have helped to forge the most influential variants of the theory. We also propose that more-rigorous quantitative methods are required to sustain theoretical development in the future.

Item ID: 17253
Item Type: Article (Refereed Research - C1)
ISSN: 1474-1741
Date Deposited: 12 Jul 2011 07:09
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110706 Immunogenetics (incl Genetic Immunology) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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