Polyspecificity of autoimmune responses in type 1 (autoimmune) diabetes

Esteban, L.M., and Baxter, A.G. (2001) Polyspecificity of autoimmune responses in type 1 (autoimmune) diabetes. Clinical and Experimental Immunology, 126 (2). pp. 184-186.

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Abstract

Autoimmunity is, by definition, supposed to be antigen specific [1], yet for almost 50 years, associations have been recognized between different autoimmune diseases [2–5]. For example, the increased incidence of gastric and thyroid autoimmunity in type 1 diabetes was first reported in 1963 [6]. These associations are in addition to the occasional cases of the autoimmune polyglandular syndromes [7] and are found independently of chronic mucocutaneous moniliasis, which is characteristic of the Type I syndrome (APECED), and Addison's disease which invariably occurs in the Type II syndrome [8].

Item ID: 17252
Item Type: Article (Commentary)
ISSN: 1365-2249
Keywords: autoimmune disease, type 1 diabetes, gastritis, systemic lupus erythematosus, thyroiditis, Grave's disease, Hashimoto's disease, Sjogren's syndrome
Additional Information:

Invited commentary

Date Deposited: 12 Jul 2011 06:23
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110706 Immunogenetics (incl Genetic Immunology) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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