LPS promotes pre-osteoclast activity by up-regulating CXCR4 via TLR-4

Xing , Q., de Vos, P., Faas, M.M., Ye, Q., and Ren, Y. (2011) LPS promotes pre-osteoclast activity by up-regulating CXCR4 via TLR-4. Journal of Dental Research, 90 (2). pp. 157-162.

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Abstract

Lipopolysaccharide (LPS) has been shown to be a prominent pathogenic factor in inflammatory bone loss. However, knowledge of the mechanisms involved is limited. The role of the SDF-1/CXCR4 (Stromal-derived factor-1 and its unique chemokine receptor) axis in LPS-induced bone loss has not been studied. The aim of this study was to investigate the role of the SDF-1/CXCR4 axis in LPS-stimulated inflammatory bone loss. The results show that LPS does not influence the expression of SDF-1/CXCR4 in osteoblasts, but up-regulates the expression of CXCR4 in pre-osteoclasts via Toll-like receptor 4, which subsequently enhances pre-osteoclast migration. Moreover, LPS promoted RANKL-induced osteoclast differentiation partially through CXCR4 up-regulation. In conclusion, the present study demonstrated, for the first time, that the up-regulated expression of CXCR4 in pre-osteoclasts by LPS stimulation is involved in LPS-induced bone resorption.

Item ID: 16220
Item Type: Article (Research - C1)
ISSN: 1544-0591
Keywords: lipopolysaccharide; pre-osteoclast; SDF-1; CXCR4; TLR-4
Date Deposited: 20 Jun 2011 03:46
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110508 Periodontics @ 70%
11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110506 Orthodontics and Dentofacial Orthopaedics @ 30%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920113 Oro-Dental Disorders @ 100%
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