Double dissociated effects of the functional TNF-α -308G/A polymorphism on processes of cognitive control

Beste, Christian, Güntürkün, Onur, Baune, Bernhard T., Domschke, Katharina, Falkenstein, Michael, and Konrad, Carsten (2011) Double dissociated effects of the functional TNF-α -308G/A polymorphism on processes of cognitive control. Neuropsychologia, 49 (2). pp. 196-202.

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Neuroimmunological factors may modulate brain functions and are important to understand the molecular basis of cognition. The tumor necrosis factor alpha (TNF-α) is known to induce neurodegenerative changes in the basal ganglia, but the cognitive effects of these changes are not understood. Since the basal ganglia are neurobiologically heterogeneous, different cognitive functions mediated by basal ganglia-prefrontal loops (response inhibition and error processing) may not necessarily be uniformly affected. Response inhibition and error processing functions were examined using event-related potentials (ERPs) and subjects (N = 71) were genotyped for the functional TNF-α -308G→A polymorphism. We show a double-dissociated effect of the functional TNF-α -308G→A polymorphism on response inhibition and error processing. While response inhibition functions were more effective in the AA/AG genotype group, error monitoring functions are adversely affected in this genotype group. In the GG genotype group, the pattern of results was vice versa. The results refine the view of the effects of TNF-α on cognitive functions.

Item ID: 15221
Item Type: Article (Research - C1)
ISSN: 1873-3514
Keywords: response inhibition, error processing, event-related potentials (ERPs), TNF-alpha polymorphism, basal ganglia
Date Deposited: 18 Jan 2011 05:24
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 100%
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