An alternative technique for the induction of autoimmune valvulitis in a rat model of rheumatic heart disease

Gorton, D., Blyth, S., Gorton, J.G, Govan, B., and Ketheesan, N. (2010) An alternative technique for the induction of autoimmune valvulitis in a rat model of rheumatic heart disease. Journal of Immunological Methods, 355 (1-2). pp. 80-85.

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Abstract

We currently use a rat model in our investigations into human rheumatic heart disease (RHD). This model traditionally involves footpad immunization with antigen emulsified in complete Freund's adjuvant (CFA). Trials to find an alternative adjuvant to CFA which produced a Th1 type response in the rats resulting in carditis were unsuccessful. However, hock immunization was found to produce the desired valvular pathology without the adverse inflammatory side-effects associated with CFA. We therefore consider the hock an ideal site for immunization, particularly when using CFA.

Item ID: 15126
Item Type: Article (Research - C1)
ISSN: 1872-7905
Keywords: rat model; rheumatic heart disease; Freund's complete adjuvant; autoimmunity
Date Deposited: 14 Dec 2010 06:11
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110801 Medical Bacteriology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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