IGF-I induces neonatal climbing-fibre plasticity in the mature rat cerebellum

Sherrard, Rachel M., and Bower, Adrian J. (2003) IGF-I induces neonatal climbing-fibre plasticity in the mature rat cerebellum. Neuroreport, 14 (13). pp. 1713-1716.

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Following unilateral transection (pedunculotomy) of the neonatal rat olivocerebellar pathway, the remaining inferior olive reinnervates the denervated hemicerebellum with correct topography. The critical period for this transcommissural reinnervation closes between postnatal days 7 and 10 but can be extended by injection of growth factors. Whether growth factor treatment can extend developmental plasticity into a mature, myelinated milieu remains unknown. Rats aged 11-30 days, underwent unilateral pedunculotomy followed 24 h later by injection of insulin-like growth factor 1 (IGF-1) into the denervated cerebellum. In all animals, IGF-1 induced transcommissural olivocerebellar reinnervation, which displayed organisation consistent with normal olivocerebellar topography even following pedunculotomy up to day 20. Thus IGF-1 can reproduce developmental neuroplasticity to promote appropriate target reinnervation in a mature myelinated environment.

Item ID: 13804
Item Type: Article (Research - C1)
ISSN: 1473-558X
Keywords: climbing fibres; IGF-I; inferior olivary complex; plasticity; Purkinje cell; reinnervation
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Date Deposited: 30 Nov 2010 03:59
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110903 Central Nervous System @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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