Ischemia and reperfusion injury of the myocardium

Endara, Santiago A., Boldery, Jason O., and Bidstrup, Benjamin P. (2001) Ischemia and reperfusion injury of the myocardium. Heart Surgery Forum, 4 (Supplement 1). 2000-03493. S40-S42.

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Prolonged interruption of coronary blood flow during heart surgery results in irreversible myocardial cell damage. Interventions such as thrombolysis, emergency percutaneous coronary angioplasty and coronary artery bypass surgery can restore blood flow to affected myocardial tissue. However, restoration of coronary blood flow following acute disruption is also accompanied by a further injurious phenomenon known as myocardial reperfusion injury. This article seeks to highlight the elements involved in this process and possible interventions to reduce its effects.

Item ID: 13223
Item Type: Article (Research - C1)
ISSN: 1522-6662
Keywords: cardiopulmonary bypass; ischemic preconditioning; myocardial reperfusion injury
Date Deposited: 30 Jul 2012 04:58
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110323 Surgery @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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