Modelling the effects of genetic and environmental factors on the risk of autoimmune disease

Baxter, Alan G. (2001) Modelling the effects of genetic and environmental factors on the risk of autoimmune disease. Journal of Autoimmunity, 16 (3). pp. 331-335.

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Abstract

The presence or absence of autoimmune disease is a qualitative outcome resulting from the combined influences of genetic, environmental and stochastic factors that interact in complex ways. Because of the nature of these interactions, the effects of risk factors that contribute to the aetiology of disease cannot be adequately assessed individually. Here, I propose an approach to multiparameter modelling of autoimmune disease that incorporates Falconer's concept of liability in a generalized linear model. Specifically, a logistic model, allied to that used to assess the influence of genetic risk factors, is suggested. The limits of modelling autoimmune disease and the requirements for data collection are also briefly discussed.

Item ID: 12091
Item Type: Article (Refereed Research - C1)
ISSN: 1095-9157
Date Deposited: 19 Oct 2010 01:23
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110703 Autoimmunity @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 100%
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