Serum androgen levels in healthy premenopausal women with and without sexual dysfunction: part A: serum androgen levels in women aged 20–49 years with no complaints of sexual dysfunction

Guay, A., Munarriz, R., Jacobson, J., Talakoub, L., Traish, A., Quirk, F., Goldstein, I., and Spark, R. (2004) Serum androgen levels in healthy premenopausal women with and without sexual dysfunction: part A: serum androgen levels in women aged 20–49 years with no complaints of sexual dysfunction. International Journal of Impotence Research, 16 (6). pp. 112-120.

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Abstract

Androgen insufficiency is a recognized cause of sexual dysfunction in men and women. Age-related decrements in adrenal and gonadal androgen levels also occur naturally in both sexes. At present, it is unclear if a woman's low serum androgen level is a reflection of the expected normal age-related decline or indicative of an underlying androgen-deficient state. We studied premenopausal women with no complaints of sexual dysfunction to help define a normal female androgen profile. In all, 60 healthy, normally menstruating women, ages 20–49 y, were studied. The Abbreviated Sexual Function Questionnaire was administered along with a detailed interview. Radioimmunoassay measurements of morning serum testosterone (T), free testosterone (fT), dehydroepiandrosterone-sulfate (DHEAS), sex hormone-binding globulin (SHBG), and free androgen index (FAI) were measured during days 8–15 of the menstrual cycle. In women 20–49 y old without complaints of sexual dysfunction, serum androgen levels exhibit a progressive stepwise decline. Comparing values obtained in women age 20–29 y to those obtained in women 40–49 y, specific hormone decrements were DHEAS 195.6–140.4 mug/dl, serum T 51.5–33.7 ng/dl, fT 1.51–1.03 pg/ml. SHBG did not change significantly in women in this age group. The FAI reflected the age-related decrease in female androgen levels. The framework for the development of a female androgen profile in women with no complaints of sexual dysfunction has been established, and an age-related decrease in testosterone and its adrenal precursor, DHEAS, has been demonstrated. The FAI mirrors these decreases and its usefulness in clinical practice is confirmed. A precipitous decline in all androgens occurs after the decade of the 20s, yet SHBG does not show a significant change throughout the premenopausal years.

Item ID: 11355
Item Type: Article (Research - C1)
ISSN: 1476-5489
Keywords: diagnostic testing; endocrinology of sexual function
Date Deposited: 07 Jun 2010 04:31
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110306 Endocrinology @ 50%
17 PSYCHOLOGY AND COGNITIVE SCIENCES > 1799 Other Psychology and Cognitive Sciences > 179999 Psychology and Cognitive Sciences not elsewhere classified @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920119 Urogenital System and Disorders @ 50%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920106 Endocrine Organs and Diseases (excl. Diabetes) @ 50%
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