Conceptual challenges of a tentative model of stress-induced depression

Baune, Bernhard (2009) Conceptual challenges of a tentative model of stress-induced depression. PLoS ONE, 4 (1). pp. 1-2.

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The concept of a stress-induced depression has recently been proposed in light of new findings from animal and human studies. Depression associated with stress involves a number of body systems such as the neuroendocrine and neurotransmitter system and the immune system including cytokines and the dysregulation of the HPA axis interacting in complex pathways. However, numerous research challenges present when addressing a tentative concept of stress-induced depression. One of them is the requirement to establish a causative relationship between stressful environmental factors and stress-related neurochemical and genetic pathways in a complex model of interaction using valid and etiological relevant animal models. Another challenge is the establishment of animal models compatible with the concept of stress-induced depression; however, chronic mild and social stress models are promising models for the study of stressfully perceived environmental events assembling stressors relevant in depression. Moreover, the consideration of individual psychological "neurotic" factors presents another major challenge in animal and human models of stress-induced depression. In addition, the study of translational implications is needed to enhance research into the validity and relevance of a tentative concept of stress-induced depression.

Item ID: 11352
Item Type: Article (Research - C1)
ISSN: 1932-6203
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Copyright: © 2009 Bernhard Baune. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Date Deposited: 27 May 2010 04:57
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 100%
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