Human papillomavirus is basal cell carcinoma - a pilot study

Iftner, Thomas, Iftner, Angelika, Buttner, Petra G., Harrison, Simone L., Glasby, Margaret, Raasch, Beverly A., and Garbe, Claus (2009) Human papillomavirus is basal cell carcinoma - a pilot study. Journal of Rural and Tropical Public Health, 8. pp. 42-44.

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Objectives: The study investigated whether test results for human papillomavirus (HPV) are influenced by the sampling site of the specimens.

Methods: The present study was a pilot study for a large case-control study currently been conducted and included 14 immune-competent north Australian patients with histologically confirmed basal cell carcinoma. Specimens assessed were the cancer tissue, peri-lesional skin, healthy skin, and eyebrow hairs. HPV types were identified by single-tube nested 'hanging droplet' polymerase chain reaction.

Results: HPV was isolated from four patients (28.6%; 95%-confidence interval = [4.0, 32.7]) with up to three of the samples from these patients testing positive for HPV. The prevalence of HPV and the types involved varied with the sampling site. All healthy skin samples were negative for HPV.

Conclusions: HPV results varied considerably with the sample site in patients with basal cell carcinoma. Therefore, the authors suggest that standardising specimen collection for HPV analysis to the cancer site should reduce the possibility of detecting HPV types unrelated to the development of skin cancer.

Item ID: 10956
Item Type: Article (Research - C1)
ISSN: 1832-2921
Keywords: human papilloma virus; basal cell carcinoma; skin cancer; standardisation of specimen collection; Aetiology
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Date Deposited: 09 May 2010 22:30
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111299 Oncology and Carcinogenesis not elsewhere classified @ 80%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 20%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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