Chaubey, Santosh K., Sinha, Ashim K., Philips, Elizabeth, Russell, Darren B., and Falhammar, Henrik (2009) Transient cardiac arrhythmias related to lopinavir/ritonavir in two patients with HIV infection. Sexual Health, 6 (3). pp. 254-257.

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Abstract

A 42-year-old Thai man was administered the combination drugs liponavir/ritonavir and abacavir/lamivudine. On day 3 he was admitted and his electrocardiogram demonstrated sinus arrest with junctional escape rhythm with a rate of 42 min-1. Three days after stopping the medication he reverted to normal sinus rhythm. A 55-year-old Caucasian man was admitted to hospital with triple vessel disease. He had a permanent pace maker inserted 4 years previously for Mobitz type II AV block detected on stress electrocardiogram, which developed 1 month after initiation of lopinavir/ritonavir. These two cases highlight the importance of considering lopinavir/ritonavir induced arrhythmias when dealing with HIV-positive individuals.

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