Neuropeptide Y (NPY) gene: impact on emotional processing and treatment response in anxious depression

Domschke, Katharina, Dannlowski, Udo, Hohoff, Christa, Ohrmann, Patricia, Bauer, Jochen, Kugel, Harald, Zwanzger, Peter, Heindel, Walter, Deckert, Jürgen, Arolt, Volker, Suslow, Thomas, and Baune, Bernhard T. (2010) Neuropeptide Y (NPY) gene: impact on emotional processing and treatment response in anxious depression. European Neuropsychopharmacology, 20 (5). pp. 301-309.

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Abstract

Neuropeptide Y (NPY) has been found to play a role in the pathomechanism of both anxiety and depression. Thus, NPY is a promising candidate in the investigation of the clinical phenotype of “anxious depression”.

Five NPY gene variants were investigated for an influence on antidepressant treatment response in a sample of 256 patients with depression. Additionally, NPY gene impact on amygdala activation during facial emotion processing was analyzed in a subsample of 35 depressed patients.

Particularly in anxious depression, the less active NPY rs16147 −399C allele conferred slow response after 2 weeks and failure to achieve remission after four weeks of treatment. The rs16147 C allele was further associated with stronger bilateral amygdala activation in response to threatening faces in an allele-dose fashion.

The present results point towards a possible influence of functional NPY gene variation on antidepressant treatment response in anxious depression, potentially conveyed by altered emotional processing.

Item ID: 10616
Item Type: Article (Research - C1)
ISSN: 1873-7862
Keywords: pharmacogenetics; imaging genetics; depression; anxiety; NPY
Date Deposited: 16 Aug 2010 03:02
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 100%
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