Seropositivity to Burkholderia pseudomallei does not reflect the development of cell-mediated immunity

Lazzaroni, Sharon M., Barnes, Jodie L., Williams, Natasha L., Govan, Brenda L., Norton, Robert E., La Brooy, Justin T., and Ketheesan, Natkunam (2008) Seropositivity to Burkholderia pseudomallei does not reflect the development of cell-mediated immunity. Transactions of the Royal Society of Tropical Medicine and Hygiene, 102 (S1). pp. 66-70.

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Cell-mediated immunity to Burkholderia pseudomallei, the causative agent of melioidosis, provides protection from disease progression. An indirect haemagglutination assay was used to detect antibodies to B. pseudomallei in 1500 healthy donors in an endemic region of Australia. Lymphocyte proliferation, activation and cytokine expression to B. pseudomallei antigen were determined in eight donors who were seropositive and in eight age- and sex-matched controls. In North Queensland, 2.5% of the population was seropositive for B. pseudomallei, which is less than half that which was previously described. Of clinical significance was the observation that while 75% of the seropositive individuals had increased lymphocyte proliferation to B. pseudomallei antigens, there were no significant differences observed in lymphocyte activation or production of cytokines.

Item ID: 10221
Item Type: Article (Research - C1)
ISSN: 0035-9203
Keywords: melioidosis; Burkholderia pseudomallei; seroprevalance; indirect haemagglutination assay; cell-mediated immunity; antibodies
Date Deposited: 25 Mar 2010 23:11
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110801 Medical Bacteriology @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 40%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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