Measurement of retinal vessel widths from fundus images based on 2-D modeling

Lowell, J, Hunter, A, Steel, D, Basu , A, Ryder, R, and Kennedy, R. L. (2004) Measurement of retinal vessel widths from fundus images based on 2-D modeling. IEEE Transactions on Medical Imaging, 23 (10). pp. 1196-1204.

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Changes in retinal vessel diameter are an important sign of diseases such as hypertension, arteriosclerosis and diabetes mellitus. Obtaining precise measurements of vascular widths is a critical and demanding process in automated retinal image analysis as the typical vessel is only a few pixels wide. This paper presents an algorithm to measure the vessel diameter to subpixel accuracy. The diameter measurement is based on a two-dimensional difference of Gaussian model, which is optimized to fit a two-dimensional intensity vessel segment. The performance of the method is evaluated against Brinchmann-Hansen's half height, Gregson's rectangular profile and Zhou's Gaussian model. Results from 100 sample profiles show that the presented algorithm is over 30% more precise than the compared techniques and is accurate to a third of a pixel.

Item ID: 10159
Item Type: Article (Research - C1)
ISSN: 1558-254X
Date Deposited: 19 Apr 2010 04:27
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
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