Publications by: Hayley L. Letson

Also publishes as (Hayley Louise Letson, Hayley Letson, Hayley I. Letson, H.L. Letson)

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Number of items: 80.

Davenport, Lisa M., Letson, Hayley L., and Dobson, Geoffrey P. (2023) Lung protection after severe thermal burns with adenosine, lidocaine, and magnesium (ALM) resuscitation and importance of shams in a rat model. Journal of Burn Care and Research. irad127. (In Press)

Chequer de Souza, Julia, Letson, Hayley L., Gibbs, Clinton R., and Dobson, Geoffrey P. (2023) The burden of head trauma in rural and remote North Queensland, Australia. Injury. 111181. (In Press)

Morris, Jodie L., McEwen, Peter C., Letson, Hayley L., and Dobson, Geoffrey P. (2023) Adenosine, Lidocaine and Magnesium (ALM) therapy modulates early sex-specific inflammatory and immune responses following experimental anterior cruciate ligament rupture and reconstruction. Translational Medicine Communications, 8. 14.

Dobson, Geoffrey P., Morris, Jodie L., and Letson, Hayley L. (2023) Adenosine, lidocaine and Mg2+ update: teaching old drugs new tricks. Frontiers in Medicine, 10. 1231759.

Letson, Hayley, Morris, Jodie, and Dobson, Geoffrey (2023) Changes in plasma alpha-1 acid glycoprotein following hemorrhagic trauma: Possible role in dose differences of ALM drug therapy in rat and pig resuscitation. Pharmacology Research & Perspectives, 11 (5). e01133.

Engstrom, Nathan, Letson, Hayley Louise, Ng, Kevin, and Dobson, Geoffrey Phillip (2022) Predicting arrhythmias in primary prevention heart failure patients: picking up the fragments. Open Heart, 9 (2). e002075.

Letson, Hayley L., Biros, Erik, Morris, Jodie L., and Dobson, Geoffrey P. (2022) ALM fluid therapy shifts sympathetic hyperactivity to parasympathetic dominance in the rat model of non-compressible hemorrhagic shock. Shock, 57 (2). pp. 264-273.

Letson, Hayley L., Morris, Jodie L., Biros, Erik, and Dobson, Geoffrey P. (2022) ALM induces cellular quiescence in the surgical margin 3 d following liver resection, hemorrhage, and shock. Journal of Surgical Research, 275. pp. 16-28.

Morris, Jodie, McEwen, Peter, Letson, Hayley, and Dobson, Geoffrey (2022) Anterior Cruciate Ligament Reconstruction Surgery: Creating a Permissive Healing Phenotype in Military Personnel and Civilians for Faster Recovery. Military Medicine, 187 (11-12). pp. 1310-1317.

Morris, Jodie L., Letson, Hayley L., Biros, Erik, McEwen, Peter C., and Dobson, Geoffrey P. (2022) Female rats have a different healing phenotype than males after anterior cruciate ligament rupture with no intervention. Frontiers in Medicine, 9. 976980.

Engstrom, Nathan, Dobson, Geoffrey, Kevin, Ng, and Letson, Hayley (2022) Fragmented QRS is associated with ventricular arrhythmias in heart failure patients: a systematic review and meta-analysis. Annals of Noninvasive Electrocardiology, 27 (1). e12910.

Dobson, Geoffrey P., Morris, Jodie L., and Letson, Hayley L. (2022) Immune dysfunction following severe trauma: A systems failure from the central nervous system to mitochondria. Frontiers in Medicine, 9. 968453.

Dobson, Geoffrey, Gibbs, Clinton, Poole, Lee, Butson, Ben, Lawton, Luke D., Morris, Jodie L., and Letson, Hayley (2022) Trauma care in the tropics: addressing gaps in treating injury in rural and remote Australia. Rural and Remote Health, 22. 6928.

Engstrom, Nathan, Dobson, Geoffrey P., Ng, Kevin, Lander, Krystle, Win, Kyi, Gupta, Anudeep, and Letson, Hayley L. (2022) Validation of CalECG software for primary prevention heart failure patients: Reducing inter-observer measurement variability. Journal of Electrocardiology, 74. pp. 128-133.

Dobson, Geoffrey P., Morris, Jodie L., and Letson, Hayley L. (2022) Why are bleeding trauma patients still dying? Towards a systems hypothesis of trauma. Frontiers in Physiology, 13. 990903.

Letson, Hayley, and Dobson, Geoffrey (2021) Buprenorphine analgesia reduces survival with ALM resuscitation in a rat model of uncontrolled hemorrhage: concerns for trauma-related research. Shock, 55 (3). pp. 379-387.

Conner, Jeff, Lammers, Daniel, Holtestaul, Torbjorg, Jones, Ian, Kuckelman, John, Letson, Hayley, Dobson, Geoffrey, Eckert, Matthew, and Bingham, Jason (2021) Combatting ischemia reperfusion injury from resuscitative endovascular balloon occlusion of the aorta (REBOA) using adenosine, lidocaine and magnesium: a pilot study. Journal of Trauma and Acute Care Surgery, 91 (6). pp. 995-1001.

Morris, Jodie L., Letson, Hayley L., McEwen, Peter, Biros, Erik, Dlaska, Constantin, Hazratwala, Kaushik, Wilkinson, Matthew, and Dobson, Geoffrey P. (2021) Comparison of intra‑articular administration of adenosine, lidocaine and magnesium solution and tranexamic acid for alleviating postoperative inflammation and joint fibrosis in an experimental model of knee arthroplasty. Journal of Orthopaedic Surgery and Research, 16. 726.

Morris, Jodie L., Letson, Hayley L., McEwen, Peter, Biros, Erik, Dlaska, Constantin, Hazratwala, Kaushik, Wilkinson, Matthew, and Dobson, Geoffrey P. (2021) Intra-articular Adenosine, Lidocaine and Magnesium (ALM) solution decreases postoperative joint fibrosis in an experimental knee implant model. Translational Medicine Communications, 6. 4.

Dobson, Geoffrey P., Biros, Erik, Letson, Hayley L., and Morris, Jodie L. (2021) Living in a hostile world: inflammation, new drug development, and coronavirus. Frontiers in Immunology, 11. 610131.

Dobson, Geoffrey P., Morris, Jodie L., Biros, Erik, Davenport, Lisa M., and Letson, Hayley L. (2021) Major surgery leads to a proinflammatory phenotype: differential gene expression following a laparotomy. Annals Of Medicine And Surgery, 71. 102970.

Sharma, Chinmay, Dobson, Geoffrey P., Davenport, Lisa, Morris, Jodie L., and Letson, Hayley L. (2021) The role of matrix metalloproteinase-9 and its inhibitor TIMP-1 in burn injury: a systematic review. International Journal of Burns and Trauma, 11 (4). pp. 275-288.

Letson, Hayley L., and Dobson, Geoffrey P. (2021) The role of nitric oxide in the efficacy of adenosine, lidocaine and magnesium (ALM) treatment of experimental hemorrhagic shock in rats. Current Therapeutic Research, 95. 100655.

Letson, Hayley L., Granfeldt, Asger, Jensen, Thomas H., Mattson, Thomas H., and Dobson, Geoffrey P. (2020) Adenosine, lidocaine, and magnesium support a high flow, hypotensive, vasodilatory state with improved oxygen delivery and cerebral protection in a pig model of noncompressible hemorrhage. Journal of Surgical Research, 253. pp. 127-138.

Letson, Hayley L., and Dobson, Geoffrey P. (2020) Buprenorphine analgesia: new adverse effects emerge. Shock, 54 (2). p. 272.

Dobson, Geoffrey P., and Letson, Hayley L. (2020) Far forward gaps in hemorrhagic shock and prolonged field care: an update of ALM fluid therapy for field use. Journal of Special Operations Medicine, 20 (3). pp. 128-134.

Tobin, Joshua M., Gavitt, Brian J., Nomellini, Vanessa, Dobson, Geoffrey P., Letson, Hayley L., and Shackelford, Stacy A. (2020) Immunotherapeutic options for inflammation in trauma. Journal of Trauma and Acute Care Surgery, 89 (25). S77-S82.

Elsiwy, Yassin, Symonds, Tristan, Doma, Kenji, Hazratwala, Kaushik, Wilkinson, Matthew, and Letson, Hayley (2020) Pre-operative clinical predictors for cardiology referral prior to total joint arthroplasty: the 'asymptomatic' patient. Journal of Orthopaedic Surgery and Research, 15. 513.

Engstrom, Nathan, Dobson, Geoffrey, Ng, Kevin, and Letson, Hayley (2020) Primary prevention implantable cardiac defibrillators: a Townsville district perspective. Frontiers in Cardiovascular Medicine, 7. 577248.

Dobson, Geoffrey P., Morris, Jodie L., Biros, Erik, and Letson, Hayley L. (2020) Specific pathogen-free animals for civilian and military trauma: a cautionary note in the translation of new drug therapies. Shock, 54 (2). pp. 232-236.

Dobson, Geoffrey P., Morris, Jodie L., Davenport, Lisa M., and Letson, Hayley L. (2020) Traumatic-induced coagulopathy as a systems failure: a new window into hemostasis. Seminars in Thrombosis and Hemostasis, 46 (2). pp. 199-214.

Dobson, Geoffrey P., Letson, Hayley L., Biros, Erik, and Morris, Jodie (2019) Specific pathogen-free (SPF) animal status as a variable in biomedical research: have we come full circle? EBioMedicine, 41. pp. 42-43.

Letson, Hayley L., and Dobson, Geoffrey Phillip (2019) Response to letter to the editor. Journal of Trauma and Acute Care Surgery, 86 (2). p. 376.

McCutchan, Andrew, Dobson, Geoffrey P., Stewart, Natalie, Letson, Hayley L., Grant, Andrea L., Jovanovic, Ivana-Aleksandra, Hazratwala, Kaushik, Wilkinson, Matthew, McEwen, Peter, and Morris, Jodie (2019) Absence of cytotoxic and inflammatory effects following in vitro exposure of chondrogenically-differentiated human mesenchymal stem cells to adenosine, lidocaine and Mg2+ solution. Journal of Experimental Orthopaedics, 6. 16.

Letson, Hayley Louise, Morris, Jodie Louise, Biros, Erik, and Dobson, Geoffrey Phillip (2019) Adenosine, lidocaine, and Mg2+ fluid therapy leads to 72-hour survival after hemorrhagic shock. Journal of Trauma and Acute Care Surgery, 87 (3). pp. 606-613.

Morris, Jodie L., Letson, Hayley L., Gillman, Rhys, Hazratwala, Kaushik, Wilkinson, Matthew, McEwen, Peter, and Dobson, Geoffrey P. (2019) The CNS theory of osteoarthritis: opportunities beyond the joint. Seminars in Arthritis and Rheumatism, 49 (3). pp. 331-336.

Letson, Hayley L., Morris, Jodie, Biros, Erik, and Dobson, Geoffrey P. (2019) Conventional and specific-pathogen free rats respond differently to anesthesia and surgical trauma. Scientific Reports, 9. 9399.

Morris, Jodie L., Letson, Hayley L., Elliott, Lisa, Grant, Andrea L., Wilkinson, Matthew, Hazratwala, Kaushik, and McEwen, Peter (2019) Evaluation of bacteriophage as an adjunct therapy for treatment of peri-prosthetic joint infection caused by Staphylococcus aureus. PLoS ONE, 14 (12). e0226574.

Morris, Jodie L., Letson, Hayley L., Grant, Andrea, Wilkinson, Matthew, Hazratwala, Kaushik, and McEwen, Peter (2019) Experimental model of peri-prosthetic infection of the knee caused by Staphylococcus aureus using biomaterials representative of modern TKA. Biology Open, 8. bio045203.

Elsiwy, Yassin, Jovanovic, Ivana, Doma, Kenji, Hazratwala, Kaushik, and Letson, Hayley (2019) Risk factors associated with cardiac complication after total joint arthroplasty of the hip and knee: a systematic review. Journal of Orthopaedic Surgery and Research, 14. 15.

Letson, Hayley L., and Dobson, Geoffrey P. (2019) Truth behind the appearances: translating new drug therapies to humans. Journal of Trauma and Acute Care Surgery, 88 (2). e105-e105.

Davenport, Lisa, Dobson, Geoffrey, and Letson, Hayley (2019) A new model for standardising and treating thermal injury in the rat. MethodsX, 6. pp. 2021-2027.

Davenport, Lisa, Dobson, Geoffrey, and Letson, Hayley (2019) The role of invasive monitoring in the resuscitation of major burns: a systematic review and meta-analysis. International Journal of Burns and Trauma, 9 (2). pp. 28-40.

Grant, Andrea L., Letson, Hayley L., Morris, Jodie L., McEwen, Peter, Hazratwala, Kaushik, Wilkinson, Matthew, and Dobson, Geoffrey P. (2018) Tranexamic acid is associated with selective increase in inflammatory markers following total knee arthroplasty (TKA): a pilot study. Journal of Orthopaedic Surgery and Research, 13. 149.

Letson, Hayley L., and Dobson, Geoffrey P. (2018) Adenosine, lidocaine, and Mg2+ (ALM) resuscitation fluid protects against experimental traumatic brain injury. Journal of Trauma and Acute Care Surgery, 84 (6). pp. 908-916.

Dobson, Geoffrey P., Doma, Kenji, and Letson, Hayley L. (2018) Clinical relevance of a p value: Does tranexamic acid save lives after trauma or postpartum hemorrhage? Journal of Trauma and Acute Care Surgery, 84 (3). pp. 532-536.

Letson, Hayley Louise, and Dobson, Geoffrey Phillip (2018) 7.5% NaCl resuscitation leads to abnormal clot fibrinolysis after severe hemorrhagic shock and its correction with 7.5% NaCl adenosine, lidocaine, and Mg2+. Journal of Emergencies, Trauma, and Shock, 11 (1). pp. 15-24.

Dobson, G.P., Letson, H.L., Grant, A., McEwen, P., Hazratwala, K., Wilkinson, M., and Morris, J.L. (2018) Defining the osteoarthritis patient: back to the future. Osteoarthritis and Cartilage, 26 (8). pp. 1003-1007.

Letson, Hayley, and Dobson, Geoffrey (2017) 3% NaCl adenosine, lidocaine, Mg2+ (ALM) bolus and 4 hours "drip" infusion reduces noncompressible hemorrhage by 60% in a rat model. Journal of Trauma and Acute Care Surgery, 82 (6). pp. 1063-1072.

Letson, Hayley, and Dobson, Geoffrey (2017) Adenosine, lidocaine and Mg²⁺ (ALM)fluid therapy attenuates systemic inflammation, platelet dysfunction and coagulopathy after non-compressible truncal hemorrhage. PLoS ONE, 12 (11). e0188144.

Griffin, Maddison J., Letson, Hayley L., and Dobson, Geoffrey P. (2017) Buprenorphine analgesia leads to coagulopathy and increased plasma fibrinogen in healthy rats: implications for small animal research. Shock, 48 (1). pp. 78-84.

Dobson, Geoffrey P., Doma, Kenji, and Letson, Hayley L. (2017) Clinical relevance of a p-value: does TXA save lives after trauma or post-partum hemorrhage? Journal of Trauma and Acute Care Surgery, 84 (3). pp. 532-536.

Davenport, Lisa, Letson, Hayley L., and Dobson, Geoffrey P. (2017) Immune-inflammatory activation after a single laparotomy in a rat model: effect of adenosine, lidocaine and Mg2+ infusion to dampen the stress response. Innate Immunity, 23 (5). pp. 482-494.

Letson, Hayley L., and Dobson, Geoffrey P. (2017) Tranexamic acid for post-partum haemorrhage in the WOMAN trial. Lancet, 390 (10102). pp. 1581-1582.

Sharma, Rajiv, Letson, Hayley L., Smith, Samuel, and Dobson, Geoffrey P. (2017) Tranexamic acid leads to paradoxical coagulation changes during cardiac surgery: a pilot rotational thromboelastometry study. Journal of Surgical Research, 217. pp. 100-112.

Dobson, Geoffrey P., Arsyad, Aryadi, and Letson, Hayley (2017) The adenosine hypothesis revisited: modulation of coupling between myocardial perfusion and arterial compliance. Frontiers in Physiology, 8. 824.

Griffin, Maddison Jade, Letson, Hayley Louise, and Dobson, Geoffrey Phillip (2016) Small-volume adenosine, lidocaine, and Mg2+ 4-hour infusion leads to 88% survival after 6 Days of experimental sepsis in the rat without antibiotics. Clinical and Vaccine Immunology, 23 (11). pp. 863-872.

Dobson, Geoffrey Phillip, and Letson, Hayley Louise (2016) Adenosine, lidocaine, and Mg2+ (ALM): from cardiac surgery to combat casualty care - teaching old drugs new tricks. Journal of Trauma and Acute Care Surgery, 80 (1). pp. 135-145.

Letson, Hayley L., and Dobson, Geoffrey (2016) Differential contributions of platelets and fibrinogen to early coagulopathy in a rat model of hemorrhagic shock. Thrombosis Research, 141. pp. 58-65.

Letson, Hayley Louise (2016) Development of a small-volume resuscitation fluid for trauma victims. PhD thesis, James Cook University.

Letson, Hayley L., and Dobson, Geoffrey P. (2015) Correction of acute traumatic coagulopathy with small-volume 7.5% NaCl adenosine, lidocaine, and Mg2+ occurs within 5 minutes: a ROTEM analysis. Journal of trauma and acute care surgery, 78 (4). pp. 773-783.

Dobson, Geoffrey P., Letson, Hayley L., Sharma, Rajiv, Sheppard, Forest R., and Cap, Andrew P. (2015) Mechanisms of early trauma-induced coagulopathy: the clot thickens or not? Journal of Trauma and Acute Care Surgery, 79 (2). pp. 301-309.

Griffin, Maddison J., Letson, Hayley L., and Dobson, Geoffrey P. (2014) Adenosine, lidocaine and Mg^2+ (ALM) induces a reversible hypotensive state, reduces lung edema and prevents coagulopathy in the rat model of polymicrobial sepsis. Journal of trauma and acute care surgery, 77 (3). pp. 471-478.

Granfeldt, Asger, Letson, Hayley L., Dobson, Geoffrey P., Shi , Wei, Vinten-Johansen, Jakob, and Tønnesen, Else (2014) Adenosine, lidocaine and Mg^2+ improves cardiac and pulmonary function, induces reversible hypotension and exerts anti-inflammatory effects in an endotoxemic porcine model. Critical Care Medicine, 18 (6). 682. pp. 1-19.

Dobson, Geoffrey P., Letson, H.L., and Tadaki, D. (2014) The Bellamy challenge: it's about time. Journal of the Royal Army Medical Corps, 160. pp. 9-15.

Griffin, Maddison, Letson, Hayley L., and Dobson, Geoffrey P. (2014) Optimization of the rodent model of polymicrobial sepsis. International Immunopharmacology, 19 (2). p. 405.

Granfeldt, Asger, Letson, Hayley L., Hyldebrandt, Janus A., Wang, Edward R., Salcedo, Pablo A., Nielsen, Torben K., Tønnesen, Else, Vinten-Johansen, Jakob, and Dobson, Geoffrey P. (2014) Small-volume 7.5% NaCI adenosine lidocaine, and Mg2+ has multiple benefits during hypotensive and blood resuscitation in the pig following severe blood loss: rat to pig translation. Critical Care Medicine, 42 (5). e329-e344.

Djabir, Yulia, Letson, Hayley L., and Dobson, Geoffrey P. (2013) Adenosine, lidocaine, and Mg²⁺ (ALM™) increases survival and corrects coagulopathy after eight-minute asphyxial cardiac arrest in the rat. Shock, 40 (3). pp. 222-232.

Letson, Hayley L., and Dobson, Geoffrey P. (2013) Acute coagulopathy of trauma in the rat. Shock, 40 (1). p. 74.

Granfeldt, Asger, Letson, Hayley L,, Dobson, Geoffrey P., Shi, WeiWei, Vinten-Johansen, Jakob, and Tønnesen, Else (2013) Cardioprotective and anti-inflammatory effects of treatment with adenocaine/mg2+ in a porcine model of endotoxemia. Circulation, 128 (122). A195.

Letson, Hayley I., Granfeldt, Asger, Hyldebrandt, Janus, Wang, Edward R., Salcedo , Pablo A., Nielsen, Torben K., Tønnesen, Else K., Vinten-Johansen, Jakob , and Dobson, Geoffrey P. (2012) Abstract 177: Rat to pig translation: small-volume 7.5% NaCl adenocaine/Mg2+ has multiple physiological benefits during hypotensive and blood resuscitation in the porcine model of severe hemorrhagic shock. In: Session IV: Best Original Resuscitation Science Poster Session (126) A177. From: Resuscitation Science Symposium, 3-6 November 2012, Los Angeles, California, USA.

Letson, Hayley L., Pecheniuk, Natalie M., Mhango, Lebo P., and Dobson, Geoffrey P. (2012) Reversal of acute coagulopathy during hypotensive resuscitation using small-volume 7.5% NaCl adenocaine and Mg2+ in the rat model of severe hemorrhagic shock. Critical Care Medicine, 40 (8). pp. 2417-2422.

Granfeldt, Asger, Letson, Hayley L., Hyldebrandt, Janus A, Wang, Edward R., Salcedo, Pablo A., Nielsen, Torben K., Tønnesen, Else , Vinten-Johansen, Jakob , and Dobson, Geoffrey P. (2012) Small-volume 7.5% NaCl adenocaine/Mg2+ preserves cardiac function during hypotensive resuscitation in the pig following severe hemorrhagic shock. In: Session III: Best of the Best Oral Abstract Presentations (126) A4. From: Resuscitation Science Symposium, 3-6 November 2012, Los Angeles, California, USA.

Letson, Hayley L., and Dobson, Geoffrey P. (2011) Unexpected 100% survival following 60% blood loss using small-volume 7.5% NaCl with Adenocaine and mg2+ in the rat model of extreme hemorrhagic shock. Shock, 36 (6). pp. 586-594.

Letson, Hayley L., and Dobson, Geoffrey P. (2011) Ultra-small intravenous bolus of 7.5% NaCl/Mg2+ with adenosine and lidocaine improves early resuscitation outcome in the rat after severe hemorrhagic shock in vivo. Journal of Trauma, 71 (3). pp. 708-719.

Letson, Hayley L., and Dobson, Geoffrey P. (2011) Small volume 7.5% NaCl With 6% dextran-70 or 6% and 10% hetastarch are associated with arrhythmias and death after 60 minutes of severe hemorrhagic shock in the rat in vivo. Journal of Trauma, 70 (6). pp. 1444-1452.

Letson, Hayley L., Pecheniuk, Natalie M., Mhango, Lebo P., and Dobson, Geoffrey P. (2011) Reversal of acute coagulopathy using small-volume 7.5% NaCl with adenocaine and Mg2+ resuscitation in a rat model of severe hemorrhagic shock. Circulation, 124 (21 Supplement). A280. p. 1.

Letson, Hayley L., and Dobson, Geoffrey P. (2010) 7.5% NaCl with adenosine, lidocaine and Mg2+ (ALM) improves hypotensive resuscitation in the pressure-controlled rat model of severe hemorrhagic shock. Circulation, 122 (21). A5.

Letson, Hayley L., and Dobson, Geoffrey P. (2010) 7.5% NaCl with adenosine, lidocaine and Mg2+(ALM) improves hypotensive resuscitation in the pressure-controlled rat model of severe hemorrhagic shock. Circulation, 122 (21). 5. A5-A5.

Letson, Hayley L., and Dobson, Geoffrey P. (2010) Surviving 60% blood loss using 7.5% NaCl with adenosine, lidocaine and magnesium (ALM) in the rat model of battlefield hemorrhagic shock. Circulation, 122 (Supplement 21). A292.

This list was generated on Fri Mar 29 23:45:55 2024 AEST.