Cerebral Phaeohyphomycosis caused by Cladophialophora bantiana in a patient with chronic Lymphocytic Leukemia

Hanieh, S., Miller, R., Daveson, L., Oman, K., and Norton, R. (2006) Cerebral Phaeohyphomycosis caused by Cladophialophora bantiana in a patient with chronic Lymphocytic Leukemia. Clinical Microbiology Newsletter, 28 (14). pp. 110-112.

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Abstract

The phaeohyphomycoses are infections caused by dematiaceous fungi. The dark pigmentation results from the melanin in their cell walls, which may be one of the factors responsible for the virulence and pathogenic potential of these fungi (1). Cladophialophora bantiana is highly neurotropic and accounts for the majority of cases of cerebral phaeohyphomycosis. Unlike many of the opportunistic fungi, most reported cases of cerebral phaeohyphomycosis caused by C. bantiana have occurred in immunocompetent patients. C. bantiana infection is often reported as being resistant to conventional medical therapy and as having an overall poor prognosis, regardless of immune status. Medical therapy is not standardized, and clinical experience with the newer azoles, such as voriconazole, has been limited.

Item ID: 9489
Item Type: Article (Case Study)
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ISSN: 1873-4391
Date Deposited: 27 Jul 2010 04:15
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110303 Clinical Microbiology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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