Apoptotic gene expression in Alzheimer disease: a preliminary report

Margolis, Stephen A. , Hammond, Kate D., and Qureshi, M.M. (2005) Apoptotic gene expression in Alzheimer disease: a preliminary report. Middle East Journal of Age and Ageing, 2 (1). pp. 1-5.

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Abstract

Background: This preliminary study examined the pattern of apoptotic gene expression in Alzheimer Disease [AD] using RNA from whole blood.

Methods: Venous blood samples were collected from 8 Gulf Arab people aged 60+ years with AD and 12 ethnically similar controls. RNA was isolated using the PAXgene blood RNA procedure and analysed using a GEArray system, profiling 96 key apoptotic genes. Results: In all samples, TNFRSF1B (TNF receptor family TNFR2) was the most highly expressed; BCL2L1 (BCL2 family bcl-x) and CASP14 (caspase family) were also of relatively high intensity. In AD, BCL2L1 was significantly lower than in controls [p=0.022]. TNFSF14 (HVEM-L) was significantly higher in males than females [p=0.025]. There was no difference in expression of the other apoptotic genes observed.

Conclusion: The findings suggest a possible role for the anti-apoptotic gene BCL2L1 in AD and a possible differential role between sexes in ageing for TNFSF14.

Item ID: 9462
Item Type: Article (Refereed Research - C1)
Keywords: ageing; blood; RNA; gene expression; Alzheimer disease; apoptosis
ISSN: 1449-8677
Date Deposited: 24 Mar 2010 04:39
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110308 Geriatrics and Gerontology @ 100%
SEO Codes: 92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920502 Health Related to Ageing @ 100%
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