Blood RNA concentration in Alzheimer disease and vascular dementia
Margolis, Stephen A., Hammond, Kate D, and Qureshi, M M. (2004) Blood RNA concentration in Alzheimer disease and vascular dementia. Middle East Journal of Age and Ageing, 1 (2). pp. 1-4.
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Background: To determine if blood RNA concentrations are altered in people with Alzheimer disease [AD] or vascular dementia [VaD]. Methods: Venous blood samples were collected from a population sample of 31 people aged 60+ years, living in an aged care residential centre, with AD or VaD, 20 randomly selected aged controls, living in the community, with normal cognition and no history of cerebrovascular disease and a convenience sample of 20 healthy young controls. Results: Total RNA was successfully extracted from the blood with the PAXGENE RNA system. There was a statistically significant difference in the blood RNA concentration between those with AD [n = 15, mean = 3.0 +/- 0.9], VaD [n = 15, mean = 3.7 +/- 1.4], young controls [n = 18, mean = 4.5 +/- 1.4] and aged controls [n = 19. mean = 5.0 +/- 1.1] [F= 9.05; p<0.0001], including when controlled for age [F=7.09, p<0.0001]. The RNA concentration in AD was statistically significantly lower than the aged controls [p<0.0001] and young controls [p=0.003]. RNA in VaD was statistically significantly lower than the aged controls [p=0.02]. Conclusion: As total blood RNA concentrations were lower in those with AD or VAD in this population based sample, further studies may be needed to ascertain the significance of this preliminary finding.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||blood; RNA; Alzheimer disease; vascular dementia.|
|Date Deposited:||14 May 2010 01:49|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110308 Geriatrics and Gerontology @ 100%|
|SEO Codes:||92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920502 Health Related to Ageing @ 100%|