Blood RNA concentration in Alzheimer disease and vascular dementia

Margolis, Stephen A., Hammond, Kate D, and Qureshi, M M. (2004) Blood RNA concentration in Alzheimer disease and vascular dementia. Middle East Journal of Age and Ageing, 1 (2). pp. 1-4.

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Abstract

Background: To determine if blood RNA concentrations are altered in people with Alzheimer disease [AD] or vascular dementia [VaD]. Methods: Venous blood samples were collected from a population sample of 31 people aged 60+ years, living in an aged care residential centre, with AD or VaD, 20 randomly selected aged controls, living in the community, with normal cognition and no history of cerebrovascular disease and a convenience sample of 20 healthy young controls. Results: Total RNA was successfully extracted from the blood with the PAXGENE RNA system. There was a statistically significant difference in the blood RNA concentration between those with AD [n = 15, mean = 3.0 +/- 0.9], VaD [n = 15, mean = 3.7 +/- 1.4], young controls [n = 18, mean = 4.5 +/- 1.4] and aged controls [n = 19. mean = 5.0 +/- 1.1] [F= 9.05; p<0.0001], including when controlled for age [F=7.09, p<0.0001]. The RNA concentration in AD was statistically significantly lower than the aged controls [p<0.0001] and young controls [p=0.003]. RNA in VaD was statistically significantly lower than the aged controls [p=0.02]. Conclusion: As total blood RNA concentrations were lower in those with AD or VAD in this population based sample, further studies may be needed to ascertain the significance of this preliminary finding.

Item ID: 9459
Item Type: Article (Refereed Research - C1)
Keywords: blood; RNA; Alzheimer disease; vascular dementia.
ISSN: 1449-8677
Date Deposited: 14 May 2010 01:49
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110308 Geriatrics and Gerontology @ 100%
SEO Codes: 92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920502 Health Related to Ageing @ 100%
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