Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells

Millington, Owain R., Gibson, Vivienne B., Rush, Catherine M., Zinselmeyer, Bernd H., Phillips, R. Stephen, Garside, Paul, and Brewer, James M. (2007) Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells. Plos Pathogens, 3 (10). pp. 1380-1387.

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Abstract

Interactions between antigen-presenting dendritic cells (DCs) and T cells are essential for the induction of an immune response. However, during malaria infection, DC function is compromised and immune responses against parasite and heterologous antigens are reduced. Here, we demonstrate that malaria infection or the parasite pigment hemozoin inhibits T cell and DC interactions both in vitro and in vivo, while signal 1 intensity remains unaltered. This altered cellular behaviour is associated with the suppression of DC costimulatory activity and functional T cell responses, potentially explaining why immunity is reduced during malaria infection.

Item ID: 9328
Item Type: Article (Refereed Research - C1)
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ISSN: 1553-7374
Date Deposited: 08 Apr 2010 04:35
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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