Multiple deficiencies underlie NK cell inactivity in lymphotoxin-α gene knockout mice.

Smyth, Mark J., Johnstone, Ricky W., Cretney, Erika, Haynes, Nicole M., Sedgwick, Jonathon D., Korner, Heiner, Poulton, Lynn D., and Baxter, Alan G. (1999) Multiple deficiencies underlie NK cell inactivity in lymphotoxin-α gene knockout mice. Journal of Immunology, 163 (3). pp. 1350-1353.

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Abstract

We have evaluated the NK cell antitumor activity in lymphotoxin (LT)-deficient mice. Both NK cell-mediated tumor rejection and protection from experimental metastases were significantly compromised in LT-{alpha}-deficient mice. Analysis of LT-{alpha}-deficient mice revealed that the absolute number of {alpha}{beta}TCR- NK1.1+ NK cells was reduced in bone marrow and thymus, but with overall proportional decreases in other hemopoietic organs. In addition, the antitumor potential of {alpha}{beta}TCR- NK1.1+ cells, as determined by their lytic capacity and perforin expression, was reduced 1.5- to 3-fold in LT-{alpha}-deficient mice, as compared with wild-type mice. Combined defects in NK cell development and effector function contribute to compromised NK cell antitumor function in LT-{alpha}-deficient mice. Combined defects in NK cell development and effector function contribute to compromised NK cell antitumor function in LTa- deficient mice.

Item ID: 8415
Item Type: Article (Refereed Research - C1)
ISSN: 1550-6606
Date Deposited: 12 Aug 2010 06:58
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110703 Autoimmunity @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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