Philip, Reynold Giru (2023) Determination of structure/function relationships of bioactive peptides. PhD thesis, James Cook University.

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Abstract

Reynold Philip studied the potential of peptides, which were engineered by downsizing proteins, against inflammatory diseases (inflammatory bowel disease (IBD), allergic asthma) and human hookworm infection. He identified several lead molecules with either potential in treating allergic asthma or as a candidate for developing a hookworm vaccine. Interestingly, a conserved sequence motif was identified with anti-inflammatory activity that appears to be widespread in nature.

Item ID:	81100
Item Type:	Thesis (PhD)
Keywords:	peptides with anti-inflammatory activity, inflammatory diseases, inflammatory bowel disease, allergic asthma, human hookworm infection, hookworm vaccine, conserved sequence motif, lunasin
Copyright Information:	Copyright © 2023 Reynold Giru Philip
Date Deposited:	11 Dec 2023 23:07
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3205 Medical biochemistry and metabolomics > 320506 Medical biochemistry - proteins and peptides (incl. medical proteomics) @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320402 Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies) @ 50%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 50% 20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 50%
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