Development of peptides as potential drug leads for the treatment of inflammatory bowel diseases
Cobos Caceres, Claudia (2018) Development of peptides as potential drug leads for the treatment of inflammatory bowel diseases. PhD thesis, James Cook University.
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Abstract
Claudia Cobos studied the structure/function relationships of anti-inflammatory peptides. She identified peptides that alleviated symptoms in an experimental model of colitis. These peptides have potential in the development of novel therapeutics for inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis.
| Item ID: | 76792 |
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| Item Type: | Thesis (PhD) |
| Keywords: | anti-inflammatory, peptides, TNBS, colitis mouse model, inflammation, nuclear magnetic resonance, peptide synthesis, protein structure |
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| Copyright Information: | Copyright © 2018 Claudia Cobos Caceres. |
| Additional Information: | Three publications arising from this thesis are stored in ResearchOnline@JCU, at the time of processing. Please see the Related URLs. The publications are: Chapter 2: Cobos Caceres, Claudia, Bansal, Paramjit S., Navarro, Severine, Wilson, David, Don, Laurianne, Giacomin, Paul, Loukas, Alex, and Daly, Norelle L. (2017) An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease. Journal of Biological Chemistry, 292 (24). pp. 10288-10294. Chapter 3: Cobos, Claudia, Bansal, Paramjit S., Jones, Linda, Wangchuk, Phurpa, Wilson, David, Loukas, Alex, and Daly, Norelle L. (2018) Engineering of an anti-inflammatory peptide based on the disulfide-rich linaclotide scaffold. Biomedicines, 6 (4). 97. Chapter 4: Cobos, Claudia, Bansal, Paramjit S., Wilson, David T., Jones, Linda, Zhao, Guangzu, Field, Matthew A., Eichenberger, Ramon M., Pickering, Darren A., Ryan, Rachael Y.M., Ratnatunga, Champa N., Miles, John J., Ruscher, Roland, Giacomin, Paul R., Navarro, Severine, Loukas, Alex, and Daly, Norelle L. (2022) Peptides derived from hookworm anti-inflammatory proteins suppress inducible colitis in mice and inflammatory cytokine production by human cells. Frontiers in Medicine, 9. 934852. |
| Date Deposited: | 14 Nov 2022 02:50 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3205 Medical biochemistry and metabolomics > 320506 Medical biochemistry - proteins and peptides (incl. medical proteomics) @ 50% 34 CHEMICAL SCIENCES > 3404 Medicinal and biomolecular chemistry > 340407 Proteins and peptides @ 50% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 50% 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280103 Expanding knowledge in the biomedical and clinical sciences @ 50% |
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