Rational vaccine development for malaria from genomic sequence information
Seid, Mengistu Endris (2020) Rational vaccine development for malaria from genomic sequence information. PhD thesis, James Cook University.
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DOI: 10.25903/gfn2-tc45
View at Publisher Website: https://doi.org/10.25903/gfn2-tc45
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Abstract
Malaria remains a global public health problem. Traditional vaccine development efforts spanning many decades have not been successful. Working towards a rationally designed genome-based vaccine, Mengistu Seid has characterized 14 novel P. falciparum antigens identified by proteome-wide T cell screening. Almost all antigens were immunogenic and protective against cross-species parasite challenge.
| Item ID: | 75448 |
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| Item Type: | Thesis (PhD) |
| Keywords: | Plasmodium falciparum, malaria, vaccine development, genomics, T cells, parasites |
| Copyright Information: | Copyright © 2020 Mengistu Endris Seid. |
| Date Deposited: | 11 Jul 2022 05:11 |
| FoR Codes: | 31 BIOLOGICAL SCIENCES > 3105 Genetics > 310509 Genomics @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320704 Medical parasitology @ 50% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 100% |
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