Okosun, K.O., Khan, M.A., Bonyah, E., and Ogunlade, S.A. (2017) On the dynamics of HIV-AIDS and cryptosporidiosis. European Physical Journal Plus, 132 (8). 363. pp. 338-363.

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Abstract

This paper seeks to examine a mathematical model for cryptosporidiosis-HIV co-infection, in order to explore their synergistic relationship in the presence of prevention and treatment. Firstly, we investigate the sub-models and their steady states properties. They are found to be locally and globally stable. Thereafter, the steady states of the co-infected model waswere studied and itthey proved to exhibit backward bifurcation phenomena. Furthermore, we incorporate time-dependent controls in the model and apply Pontryagin’s maximum principle, so that we can determine the best optimal strategy to control the co-infected diseases. Finally, we present the numerical results, which show that the best strategy to control co-infection is to combine all the five controls at the same time.

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