New developments in the management of major depressive disorder and generalized anxiety disorder: role of quetiapine

Baune, Bernhard T. (2008) New developments in the management of major depressive disorder and generalized anxiety disorder: role of quetiapine. Neuropsychiatric Disease and Treatment, 4 (6). pp. 1181-1191.

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Abstract

Quetiapine has demonstrated efficacy in schizophrenia, bipolar disorder and in the treatment of specific symptom clusters such as agitation and sleep problems in mood disorders. In this review, randomized controlled studies demonstrating efficacy, safety and tolerability of quetiapine in major depressive disorder (MDD) and general anxiety disorder (GAD) are evaluated. The results show that quetiapine monotherapy and quetiapine augmentation of antidepressant treatment in MDD and GAD are efficacious for short-term and maintenance treatment at a dose range between 50 and 300 mg/day. Quetiapine appears to have a specific but overall mild side-effect profile, though, some adverse effects such as sedation and somnolence may lead to withdrawal from treatment in some patients. Overall, the available evidence suggests that there is a significant role for quetiapine in the treatment of MDD and GAD.

Item ID: 6953
Item Type: Article (Refereed Research - C1)
Keywords: quetiapine; major depressive disorders; general anxiety disorder; randomized controlled studies; adverse effects
ISSN: 1178-2021
Date Deposited: 30 Mar 2010 23:46
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110319 Psychiatry (incl Psychotherapy) @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 100%
Citation Count from Scopus Scopus 11
Downloads: Total: 2
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