13-Epi-9-deacetoxyxenicin, a Cytotoxic Diterpene from the soft coral Asterospicularia laurae (Alcyonacea)
Bowden, Bruce F., Cusack, Bernard J., and Dangel, Alissa (2003) 13-Epi-9-deacetoxyxenicin, a Cytotoxic Diterpene from the soft coral Asterospicularia laurae (Alcyonacea). Marine Drugs, 1 (1). pp. 18-26.
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An investigation of the soft coral Asterospicularia laurae collected on the Great Barrier Reef, Australia, afforded the cytotoxic diterpene 13-epi-9-deacetoxyxenicin (1) in addition to the known metabolites 13-epi-9-deacetylxenicin (2) and gorgosterol. 13-Epi-9-deacetoxyxenicin readily underwent an autoxidation reaction in solution to afford a single product, the hydroperoxide 3. Structures, stereochemistry, and NMR assignments were established by high resolution NMR spectroscopy and by comparison with published data for known compounds.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||Asterospicularia; Cytotoxicity; marine natural products; soft corals; xenicane diterpene|
|Date Deposited:||24 Jan 2010 23:00|
|FoR Codes:||03 CHEMICAL SCIENCES > 0305 Organic Chemistry > 030599 Organic Chemistry not elsewhere classified @ 100%|
|SEO Codes:||97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 100%|
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