Polarized arrest with warm or cold adenosine/lidocaine blood cardioplegia is equivalent to hypothermic potassium blood cardioplegia

Corvera, Joel S., Kin, Hajime, Dobson, Geoffrey P., Kerendi, Faraz, Halkos, Michael E., Katzmark, Sara, Payne, Christopher S., Zhao, Zhi-Qing, Guyton, Robert A., and Vinten-Johansen, Jakob (2005) Polarized arrest with warm or cold adenosine/lidocaine blood cardioplegia is equivalent to hypothermic potassium blood cardioplegia. Journal of Thoracic and Cardiovascular Surgery, 129 (3). pp. 599-606.

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Abstract

Background: Hypothermic depolarizing hyperkalemic (K+ 20 mEq/L) blood cardioplegia is the “gold standard” in cardiac surgery. K+ has been associated with deleterious consequences, eg, intracellular calcium overload. This study tested the hypothesis that elective arrest in a polarized state with adenosine (400 μmol/L via adenosine triphosphate–sensitive potassium channel opening) and the Na+ channel blocker lidocaine (750 μmol/L) as the arresting agents in blood cardioplegia provides cardioprotection comparable to standard hypothermic K+-blood cardioplegia.

Methods: Anesthetized dogs were placed on cardiopulmonary bypass and assigned to 1 of 3 groups receiving antegrade cardioplegia delivered every 20 minutes for 1 hour of arrest: cold (10°C) K+-blood cardioplegia (n = 6), cold (10°C) adenosine/lidocaine blood cardioplegia (n = 6), or warm (37°C) adenosine/lidocaine blood cardioplegia (n = 6). After an hour of arrest, cardiopulmonary bypass was discontinued, and reperfusion was continued for 120 minutes.

Results: Time to arrest was longer with cold and warm adenosine/lidocaine blood cardioplegia (175 ± 19 seconds and 143 ± 19 seconds, respectively) compared with K+-blood cardioplegia (27 ± 2 seconds; P < .001). Postcardioplegia left ventricular systolic function (slope of the end-systolic pressure/dimension relationship) was comparable among the 3 groups (K+-blood cardioplegia, 15.2 ± 2.1 mm Hg/mm; cold adenosine/lidocaine blood cardioplegia, 15.9 ± 3.4 mm Hg/mm; warm adenosine/lidocaine blood cardioplegia, 14.1 ± 2.8 mm Hg/mm; P = .90). Plasma creatine kinase activity in cold and warm adenosine/lidocaine blood cardioplegia was similar to that in K+-blood cardioplegia at 120 minutes of reperfusion (cold adenosine/lidocaine blood cardioplegia, 11.5 ± 2.1 IU/g protein; warm adenosine/lidocaine blood cardioplegia, 10.1 ± 0.9 IU/g protein; K+-blood cardioplegia, 7.6 ± 0.8 IU/g protein; P = .17). Postcardioplegia coronary artery endothelial function was preserved in all groups.

Conclusions: Intermittent polarized arrest with warm or cold adenosine/lidocaine blood cardioplegia provided the same degree of myocardial protection as intermittent hypothermic K+-blood cardioplegia in normal hearts.

Item ID: 6717
Item Type: Article (Refereed Research - C1)
ISSN: 1097-685X
Date Deposited: 24 Mar 2010 01:01
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1116 Medical Physiology > 111603 Systems Physiology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
Citation Count from Web of Science Web of Science 24
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