Melatonin generates singlet oxygen on laser irradiation but acts as a quencher when irradiated by lamp photolysis
Maharaj, D.S., Molell, H., Antunes, E.M., Maharaj, H., Maree, D.M., Nyokong, T., Glass, B.D., and Daya, S. (2005) Melatonin generates singlet oxygen on laser irradiation but acts as a quencher when irradiated by lamp photolysis. Journal of Pineal Research, 38 (3). pp. 153-156.
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Melatonin, a naturally occurring chemical mediator, although assigned a diverse range of functions, has attracted interest in recent years because of its ability to function as a free radical scavenger. Because of the implications of singlet oxygen in neurotoxicity, the objective of the study was to investigate the ability of melatonin to quench singlet oxygen generated using laser irradiation or lamp photolysis. The results show that melatonin produces radicals upon laser irradation while the lamp photolysis studies show that melatonin is able to scavenge singlet oxygen produced by naphthalene. While melatonin is a free radical scavenger under biological conditions, it acts as a generator of singlet oxygen and or radicals (as ΦΔ is 1.41) when irradiated with laser light, implying that it has the potential to be used in photodynamic therapy in the destruction of tumors.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||cytotoxicity; melatonin; oxidative stress; photodynamic therapy; singlet oxygen; cytotoxic|
|Date Deposited:||08 Feb 2010 02:27|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified @ 100%|
|SEO Codes:||86 MANUFACTURING > 8608 Human Pharmaceutical Products > 860899 Human Pharmaceutical Products not elsewhere classified @ 100%|
|Citation Count from Web of Science||