Deregulation of the 2,5A Synthetase Rnase L Antiviral pathway by Mycoplasma spp. in subsets of chronic fatigue syndrome

Nijs, Jo, De Meirleir, Kenny, Coomans, Danny, De Becker, Pascale, and Nicolson, Garth L. (2003) Deregulation of the 2,5A Synthetase Rnase L Antiviral pathway by Mycoplasma spp. in subsets of chronic fatigue syndrome. Journal of Chronic Fatigue Syndrome, 11 (2). pp. 37-50.

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Abstract

The deregulation of the 2,5A synthetase RNase L antiviral pathway and the prevalence of Mycoplasma spp. in subsets of Chronic Fatigue Syndrome (CFS) have been separately reported in the scientific literature. We hypothesised that a co-morbid pathophysiological mechanism involving infection by Mycoplasma spp. and the deregulation of the 2,5A synthetase/RNase L antiviral pathway may exist in CFS. Therefore, 186 consecutive CFS patients were enrolled. Mycoplasma detection was performed using forensic polymerase chain reaction. For RNase L determination, a radioactive probe was used to label 2,5A binding proteins in unfractionated peripheral blood mononuclear cell extracts. Myco-plasma-infected CFS patients presented with significantly elevated RNase L-ratio, compared to non-infected age- and sex-matched patients (p = 0.016). These results suggest that mycoplasma infections may cause deregulation of the 2,5A synthetase RNase L antiviral pathway in patients with CFS

Item ID: 6543
Item Type: Article (Refereed Research - C1)
Keywords: 2,5A synthetase Rnase L antiviral pathway; chronic fatigue syndrome; mycoplasma
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ISSN: 1057-3321
Date Deposited: 05 Apr 2010 23:52
FoR Codes: 01 MATHEMATICAL SCIENCES > 0104 Statistics > 010401 Applied Statistics @ 100%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
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