Decomposition of solids accompanied by melting - Bawn kinetics

Brown, Michael E., and Glass, Beverley D. (2003) Decomposition of solids accompanied by melting - Bawn kinetics. International Journal of Pharmaceutics, 254 (2). pp. 255-261.

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Abstract

The book “Chemistry of the Solid State”, edited by W.E. Garner more than 50 years ago, contained a chapter (Chapter 10) by C.E.H. Bawn which dealt with the kinetics of the thermal decompositions of solids that are accompanied by some melting. Rate equations were derived and this model has become known as the Bawn model or as “Bawn kinetics”. This kinetic model has proved particularly useful in pharmaceutical stability studies. The isothermal curves of extent of decomposition, α, against time for this model are sigmoidal and the problems of distinguishing this model from other sigmoidal models (Prout–Tompkins, Avrami–Erofeev) have been examined. Under programmed temperature conditions, distinguishability becomes even more difficult.

Item ID: 6470
Item Type: Article (Refereed Research - C1)
Keywords: Bawn model; kinetics; melting and decomposition; sigmoidal models; stability
ISSN: 1873-3476
Date Deposited: 22 Mar 2010 23:28
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified @ 100%
SEO Codes: 86 MANUFACTURING > 8608 Human Pharmaceutical Products > 860899 Human Pharmaceutical Products not elsewhere classified @ 100%
Citation Count from Web of Science Web of Science 10
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