Does carboxymethylcellulose have a role in reducing time to full enteral feeds in preterm neonates?

Patole, S.K., and Muller, R. (2005) Does carboxymethylcellulose have a role in reducing time to full enteral feeds in preterm neonates? International Journal of Clinical Practice, 59 (5). pp. 544-548.

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Abstract

The efficacy of prophylactic carboxymethylcellulose (CMC) in reducing the time to reach full enteral feeds (FEFs) in neonates <32 weeks' gestation was studied in a clinical trial. When ready for feeds, enrolled neonates were allocated to either CMC (dose: CMC content of 12 mg oral erythromycin ethyl succinate syrup, 6 hourly) or placebo till either maximum 10 days treatment or FEF (150 ml/kg/day) was reached. A standardised regimen guided enteral feeding. Demographic characteristics of enrolled neonates (CMC, placebo: n = 35) were comparable. Median (interquartile range) gestational age and birth weight were 29 (28, 30) vs. 29 (27, 31) weeks and 1090 (905, 1390) vs. 1236 g (928, 1565) for the CMC and placebo groups, respectively. Median (interquartile range) time to reach FEF was 5 (4, 6) vs. 5 (3, 8) days for CMC and placebo group, respectively (p = 0.5). No CMC-related adverse effects occurred. Prophylactic CMC did not have a significant role in reducing time to reach FEF.

Item ID: 6434
Item Type: Article (Refereed Research - C1)
Keywords: carboxmethlcellulose; enteral; feeds; neonates; preterm
ISSN: 1742-1241
Date Deposited: 15 Mar 2010 01:52
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111799 Public Health and Health Services not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920501 Child Health @ 100%
Citation Count from Web of Science Web of Science 4
Downloads: Total: 1
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