Quantitative and qualitative approaches to GOD: the first 10 years of the clonal selection theory
Jordan, Margaret A., and Baxter, Alan G. (2008) Quantitative and qualitative approaches to GOD: the first 10 years of the clonal selection theory. Immunology and Cell Biology, 86 (1). pp. 72-79.
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Of the contentious issues surrounding the clonal selection theory, one of the most influential was that of the mechanism for the generation of diversity of antibody specificity. While Burnet's qualitative theory assumed a very large antibody repertoire, Talmage provided a detailed quantitative argument supporting only 5000 individual globulin patterns that provided an antiserum its specificity through combinatorial action. This methodological difference between the two men, and the mechanistic difference between their models, is key to the understanding of the clonal selection theory, its later acceptance and the proportion of credit paid to Burnet.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||autoimmunity; specificity; tolerance|
|Date Deposited:||28 Jan 2010 06:21|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 100%|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%|
|Citation Count from Web of Science||