Does inbreeding and loss of genetic diversity decrease disease resistance?

Spielman, Derek, Brook, Barry W., Briscoe, David A., and Frankham, Richard (2004) Does inbreeding and loss of genetic diversity decrease disease resistance? Conservation Genetics, 5 (4). pp. 439-448.

[img] PDF (Published Version)
Restricted to Repository staff only

View at Publisher Website: http://dx.doi.org/10.1023/B:COGE.0000041...

Abstract

Inbreeding and loss of genetic diversity are predicted to decrease the resistance of species to disease. However, this issue is controversial and there is limited rigorous scientific evidence available. To test whether inbreeding and loss of genetic diversity affect a host''s resistance to disease, Drosophila melanogasterpopulations with different levels of inbreeding and genetic diversity were exposed separately to (a) thuringiensin, an insecticidal toxin produced by some strains of Bacillus thuringiensis, and (b) live Serratia marcescensbacteria. Inbreeding and loss of genetic diversity significantly reduced resistance of D. melanogasterto both the thuringiensin toxin and live Serratia marcescens. For both, the best fitting relationships between resistance and inbreeding were curvilinear. As expected, there was wide variation among replicate inbred populations in disease resistance. Lowered resistances to both the toxin and the pathogen in inbred populations were due to specific resistance alleles, rather than generalized inbreeding effects, as correlations between resistance and population fitness were low or negative. Wildlife managers should strive to minimise inbreeding and loss of genetic diversity within threatened populations and to minimise exposure of inbred populations to disease.

Item ID: 6127
Item Type: Article (Refereed Research - C1)
Keywords: disearse resistance; Drosophila melanogaster; genetic diversity; inbreeding; population size
ISSN: 1572-9737
Date Deposited: 11 Jan 2010 05:45
FoR Codes: 06 BIOLOGICAL SCIENCES > 0608 Zoology > 060899 Zoology not elsewhere classified @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
Citation Count from Web of Science Web of Science 99
Downloads: Total: 1
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page