Sun exposure and the incidence of melanocytic nevi in young Australian children

Harrison, Simone Lee, Maclennan, Robert, and Buettner, Petra Gertraud (2008) Sun exposure and the incidence of melanocytic nevi in young Australian children. Cancer Epidemiology, Biomarkers & Prevention, 17 (9). pp. 2318-2324.

[img] PDF (Published Version)
Restricted to Repository staff only

View at Publisher Website: http://dx.doi.org/10.1158/1055-9965.EPI-...

Abstract

The number of melanocytic nevi (MN) is an important risk factor for cutaneous melanoma. The present study further investigated the relationship between sun exposure, the incidence of MN, and the prevalence of large acquired MN (≥5 mm). A cohort of 479 preschool children born in Townsville, Australia was examined for MN in 1991 and a year later. Sun exposure was assessed by questionnaire. The erythemally effective dose of solar UV radiation was estimated from questionnaire data combined with local UV biometry. Almost all (97.7%) children had acquired new MN (median, 12), with a median incidence rate of 11.0 per year (interquartile range, 7.0-16.5). Total number of hours of sun exposure during follow-up (P = 0.034) and tendency to burn (P = 0.028) were independent risk factors for MN incidence. Sunburn experience during follow-up failed to reach significance when adjusted for tendency to burn. Lifetime number of sunburns (P < 0.001) and the severity of sunburns experienced during follow-up (P < 0.001) were significantly related to the presence of large acquired MN at follow-up. Reducing the total number of hours of sun exposure is particularly relevant in sun-sensitive children and may restrain the development of MN, whereas avoiding sunburn in young children might prevent large MN, subsequently reducing the risk of melanoma.

Item ID: 6064
Item Type: Article (Refereed Research - C1)
Keywords: Australia; longtitudinal study; moles; melanocytic nevi; sun exposure; children; risk factors; cohort study; incidence
ISSN: 1538-7755
Date Deposited: 14 Jan 2010 22:53
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111716 Preventive Medicine @ 70%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920412 Preventive Medicine @ 50%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920401 Behaviour and Health @ 50%
Citation Count from Web of Science Web of Science 21
Downloads: Total: 1
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page