Increased mortality in female rats after severe diffuse traumatic brain injury is significantly attenuated by magnesium administration

Alexiou, T, Crane, LH, and Vink, R (2000) Increased mortality in female rats after severe diffuse traumatic brain injury is significantly attenuated by magnesium administration. Neuroscience research communications, 26 (1). pp. 1-8.

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Abstract

Previous studies using focal models of traumatic brain injury have shown that female animals have a higher postinjury mortality than male animals, and that this higher mortality may be due to a worsened magnesium homeostasis in the female animals. The present study examined whether a similar difference in male and female mortality existed following a more diffuse model of traumatic brain injury and whether any mortality coule be attentuated by ovariectomy or posttraumatic magnesium administration. Severe impact-acceleration induced diffuse brain trauma resulted in a 20% mortality in male rats as opposed to a 100% mortality in female animals (p<0.05). This difference was not apparent at less severe injury levels. Administration of 750 micromoles/kg magnesium suphate intramuscularly at 30 min after severe trauma reduced female mortality to 29% (p<0.05). Female outcomes were similar in ovariectomised animals suggesting that the protective effects of magnesium were unrelated to cyclic changes in gonadal hormones. We conclude that the higher mortality observed in female animals following brain trauma is dependent on injury severity and that this mortality can be significantly attenuated with posttraumatic administration of magnesium suphate.

Item ID: 594
Item Type: Article (UNSPECIFIED)
Keywords: Neurotrauma, Brain injury, Gender, Treatment, Hormones
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© 2000 John Wiley and Sons. : This journal is available online - use hypertext links above.

ISSN: 0893-6609
Date Deposited: 09 Oct 2006
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 0%
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