Hormonal variation of rat uterine contractile responsiveness to selective neurokinin receptor agonists

Hamlin, GP, Williams, MJ, Nimmo, AJ, and Crane, LH (2000) Hormonal variation of rat uterine contractile responsiveness to selective neurokinin receptor agonists. Biology of Reproduction, 62 (6). pp. 1661-1666.

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Abstract

Regulated uterine contractions are important in many reproductive functions such as sperm transport and embryo positioning during implantation. The role of classical neurotransmitters including acetylcholine and norepinephrine in regulating myometrial contractility has been well studied; however, the peripheral role of sensory neurotransmitters such as the neurokinins is less clear. The major neurokinins are substance P, neurokinin A, and neurokinin B, which predominantly activate neurokinin receptors (NK-Rs) 1, 2, and 3, respectively. This study utilized selective receptor agonists to examine the role of NK-Rs in uterine contractility. Uterine tissues, obtained from the major stages of the rat estrous cycle, were stimulated with selective NK-R agonists. Addition of each agonist resulted in a significant contractile response. However, the magnitude and nature of the response were dependent upon the stage of the estrous cycle, with responses to all agonists being significantly decreased in tissue from proestrus and estrus. Furthermore, the nature of NK3-R-mediated contraction was different in tissue from proestrus and estrus compared to metestrus and diestrus. The hormonal dependence of NK-R-mediated contractility was then examined in the ovariectomized estrogen-supplemented rat model. These studies confirmed that the magnitude and nature of uterine contractility in response to NK-R activation depend upon the hormonal environment.

Item ID: 592
Item Type: Article (UNSPECIFIED)
Keywords: Myometrium, Neurokinin, Steroid hormone
Additional Information:

Copyright 2000 by the Society for the Study of Reproduction, Inc. This journal is available online - use hyperlinks above.

ISSN: 1529-7268
Date Deposited: 09 Oct 2006
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified @ 67%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920114 Reproductive System and Disorders @ 100%
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