Nugraha, Ari Satia, Pratoko, Dwi Koko, Damayanti, Yuvita Dian, Lestari, Nadya Dini, Laksono, Tinton Agung, Addy, Hardian Susilo, Untari, Ludmilla Fitri, Kusumawardani, Banun, and Wangchuk, Phurpa (2019) Antibacterial and anticancer activities of nine lichens of Indonesian Java Island. Journal of Biologically Active Products from Nature, 9 (1). pp. 39-46.

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Abstract

Lichen is a unique composite organism that arises from algae and fungi symbiotic relationship. There are 18,500 recorded lichen species worldwide but only limited number of global species has been tested for their biological activities. In particular, Indonesian lichens are rarely investigated. In this study, we collected and identified nine lichen species from six different locations in East Java Indonesia and screened their crude methanol extracts against gram-negative bacteria (Pseudomonas aeruginosa) and cancer cells (MCF7, Widr and Hela). While only the methanol extract of Parmelia cetrata Ach and Parmelia dilatata Vain inhibited Pseudomonas aeruginosa, most lichen extracts possessed moderate cytotoxicity. Cladonia scabriuscula methanol extract was cytotoxic against MCF7, Widr and Hela cell lines with IC50 value of 324, 324, 476 μg/mL, respectively. Moreover, methanol extract of Physcia cf. millegrana Degel indicated cytotoxicity against Hela cell line with IC50 value of 137 μg/mL. This study revealed anticancer potency of lichen of Java Island for the first time and further research is necessary for isolating the bioactive compounds.

Item ID:	57405
Item Type:	Article (Research - C1)
ISSN:	2231-1874
Keywords:	medicinal plant, lichen, Java island, phytochemical, antimicrobial, anticancer
Copyright Information:	Copyright © 2019, Har Krishan Bhalla & Sons
Funders:	PDUPTN research grant, Ministry of Research, Technology and Higher Education of the Republic of Indonesia
Date Deposited:	13 Mar 2019 02:56
FoR Codes:	34 CHEMICAL SCIENCES > 3404 Medicinal and biomolecular chemistry > 340499 Medicinal and biomolecular chemistry not elsewhere classified @ 70% 31 BIOLOGICAL SCIENCES > 3107 Microbiology > 310701 Bacteriology @ 20% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321405 Pharmaceutical sciences @ 10%
SEO Codes:	92 HEALTH > 9202 Health and Support Services > 920299 Health and Support Services not elsewhere classified @ 50% 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 25% 97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 25%
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