A 5-um filter does not reduce propofol-induced pain

Hellier, C., Newell, S., Barry, J., and Brimacombe, J. (2003) A 5-um filter does not reduce propofol-induced pain. Anaesthesia, 58 (8). pp. 802-803.

[img] PDF (Published Version)
Restricted to Repository staff only

View at Publisher Website: http://dx.doi.org/10.1046/j.1365-2044.20...

Abstract

We assessed the effectiveness of a 5-μm filter in reducing propofol-induced pain and determined whether any reduction is due to removal of contaminants or an alteration in flow characteristics. A total of 120 unpremedicated women (ASA 1-3, aged 18-70 yr) were randomly allocated to one of three equal-sized groups. In group A, propofol was drawn up and injected through an unfiltered plastic cannula. In group B, propofol was drawn up through a 5-μm filter needle and injected through an unfiltered plastic cannula. In group C, propofol was drawn up and injected through a 5-μm filter needle. Unmodified propofol from a 20-ml rubber topped vial at room temperature was used. A 22-g cannula was inserted into the largest visible vein on the dorsum of the non-dominant hand. Propofol was administered at 0.5 ml.s−1 and patients were asked about pain every 10 s until unresponsive, by a blinded observer. The pain score for the patient was the taken as the most severe pain documented. The frequency and severity of pain were similar among groups. We conclude that a 5-μm filter does not reduce pain associated with injection of propofol drawn from a vial with a rubber bung.

Item ID: 5728
Item Type: Article (Refereed Research - C1)
Keywords: anaesthetics; intravenous; pain mechanism; propofol
ISSN: 1365-2044
Date Deposited: 23 Dec 2009 03:31
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110301 Anaesthesiology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920115 Respiratory System and Diseases (incl. Asthma) @ 100%
Citation Count from Web of Science Web of Science 2
Downloads: Total: 2
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page