Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm

Golledge, Jonathan, Biros, Erik, Cooper, Matthew, Warrington, Nicole, Palmer, Lyle J., and Norman, Paul E. (2010) Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm. Atherosclerosis, 209 (2). pp. 487-491.

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Abstract

Objective: Apolipoprotein E (ApoE) genotype has been associated with systemic inflammation and athero-thrombosis however the association with abdominal aortic aneurysm (AAA) has not been previously examined. We assessed the association between ApoE genotype with AAA presence and growth, and serum C-reactive protein (CRP).

Methods: Serum concentrations of CRP (in 1358 men) and 6 single nucleotide polymorphisms (SNPs) for ApoE (in 1711 men) were examined in subjects from the Health In Men Study. 640 men with small AAAs were followed by ultrasound surveillance for a mean of 4.1 years.

Results: There was no association between ApoE genotype and AAA presence. Men heterozygote for the ApoE p.Arg176Cys polymorphism had slower AAA growth, odds ratio for AAA progression ≥ median 0.41, 95% confidence intervals 0.21–0.80, p = 0.01. Men heterozygote for the ApoE g.50093756A > G polymorphism had slightly more rapid AAA growth, odds ratio for AAA progression ≥ median 1.48, 95% confidence intervals 1.02–2.14, p = 0.04. None of the ApoE SNPs were associated with AAA growth however taking into account multiple testing. Two SNPs in ApoE were associated with serum CRP under a co-dominant model, ApoE p.Cys130Arg (SNP ID rs429358), p = 0.00003 and ApoE g.50114786A > G (SNP ID rs4420638), p = 0.00013. Adjusting for other risk factors plus serum creatinine the var epsilon4 allele was associated with lower serum CRP under a dominant model, coefficient 0.089, p = 0.002.

Conclusion: We found no consistent association between ApoE genotype and AAA. We confirmed an association between ApoE genotype and serum CRP.

Item ID: 5502
Item Type: Article (Refereed Research - C1)
Keywords: apolipoprotein E; abdominal aortic aneurysm; genotype
ISSN: 1879-1484
Date Deposited: 19 Aug 2010 22:46
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
Citation Count from Web of Science Web of Science 7
Downloads: Total: 3
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