Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury
Donkin, James J., Nimmo, Alan J., Cernak, Ibolja, Blumbergs, Peter C., and Vink, Robert (2009) Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury. Journal of Cerebral Blood Flow & Metabolism, 29 (8). pp. 1388-1398.
PDF (Published Version)
Brain edema and swelling is a critical factor in the high mortality and morbidity associated with traumatic brain injury (TBI). Despite this, the mechanisms associated with its development are poorly understood and interventions have not changed in over 30 years. Although neuropeptides and neurogenic inflammation have been implicated in peripheral edema formation, their role in the development of central nervous system edema after brain trauma has not been investigated. This study examines the role of the neuropeptide, substance P (SP), in the development of edema and functional deficits after brain trauma in rats. After severe diffuse TBI in adult male rats, neuronal and perivascular SP immunoreactivity were increased markedly. Perivascular SP colocalized with exogenously administered Evans blue, supporting a role for SP in vascular permeability. Inhibition of SP action by administration of the neurokinin-1 (NK1) antagonist, N-acetyl-L-tryptophan, at 30 mins after trauma attenuated vascular permeability and edema formation. Administration of the NK1 antagonist also improved both motor and cognitive neurologic outcomes. These findings suggest that SP release is integrally linked to the increased vascular permeability and edema formation after brain trauma, and that treatment with an NK1 receptor antagonist reduces edema and improves neurologic outcome.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||brain trauma; cerebral edema; neurogenic inflammation; neuropeptides|
|Date Deposited:||16 Oct 2009 04:32|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 100%|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 100%|
|Citation Count from Scopus||
Last 12 Months: 4