Combining contact tracing with targeted indoor residual spraying significantly reduces dengue transmission
Vazquez-Prokopec, Gonzalo M., Montgomery, Brian L., Horne, Peter, Clennon, Julie A., and Ritchie, Scott A. (2017) Combining contact tracing with targeted indoor residual spraying significantly reduces dengue transmission. Science Advances, 3 (2). e1602024.
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Abstract
The widespread transmission of dengue viruses (DENV), coupled with the alarming increase of birth defects and neurological disorders associated with Zika virus, has put the world in dire need of more efficacious tools for Aedes aegypti–borne disease mitigation. We quantitatively investigated the epidemiological value of location-based contact tracing (identifying potential out-of-home exposure locations by phone interviews) to infer transmission foci where high-quality insecticide applications can be targeted. Space-time statistical modeling of data from a large epidemic affecting Cairns, Australia, in 2008–2009 revealed a complex pattern of transmission driven primarily by human mobility (Cairns accounted for ~60% of virus transmission to and from residents of satellite towns, and 57% of all potential exposure locations were nonresidential). Targeted indoor residual spraying with insecticides in potential exposure locations reduced the probability of future DENV transmission by 86 to 96%, compared to unsprayed premises. Our findings provide strong evidence for the effectiveness of combining contact tracing with residual spraying within a developed urban center, and should be directly applicable to areas with similar characteristics (for example, southern USA, Europe, or Caribbean countries) that need to control localized Aedes-borne virus transmission or to protect pregnant women’s homes in areas with active Zika transmission. Future theoretical and empirical research should focus on evaluation of the applicability and scalability of this approach to endemic areas with variable population size and force of DENV infection.
| Item ID: | 53962 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 2375-2548 |
| Additional Information: | This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
| Funders: | Emory Global Health Institute, Marcus Foundation (MC), National Science Foundation (NSF), National Health and Medical Research Council (NHMRC) |
| Projects and Grants: | MC project #00052002, NSF/DEB/EEID:1640698, NHMRC Senior Research Fellowship 1044698 |
| Date Deposited: | 11 Jun 2018 04:02 |
| FoR Codes: | 42 HEALTH SCIENCES > 4206 Public health > 420699 Public health not elsewhere classified @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 50% |
| SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 50% 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920404 Disease Distribution and Transmission (incl. Surveillance and Response) @ 50% |
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