Medical comorbidity affects antidepressant treatment response in patients with melancholic depression

Pohle, K., Domschke, K., Roehrs, T., Arolt, V., and Baune, B.T. (2009) Medical comorbidity affects antidepressant treatment response in patients with melancholic depression. Psychotherapy and Psychosomatics, 78 (6). pp. 359-363.

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Abstract

Background: This study aimed at the impact of medical comorbidity (MC) on response to antidepressant treatment over 6 weeks in diagnostic subtypes of patients with major depressive episode (MDE).

Methods: In a clinical sample of 241 admitted patients with MDE, MC was assessed by medical specialists and weekly response to antidepressant treatment was assessed with the Hamilton Depression Scale (HAM-D 21).

Results: Over 6 weeks of treatment, patients with melancholic depression and MC had poorer treatment response on the HAM-D scale and a worse functional outcome (GAF) as opposed to their counterparts without MC, which was first detected after 4 weeks of treatment (p = 0.02). More specifically, subjects with melancholic depression and cardiovascular or endocrinological MC showed significantly poorer treatment response over 6 weeks. Interestingly, these effects were not related to various antidepressant treatment regimens.

Conclusions: MC has a negative impact on treatment response in patients with melancholic depression.

Item ID: 5248
Item Type: Article (Refereed Research - C1)
Keywords: medical comorbidity; subtypes of depression; treatment response
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ISSN: 1423-0348
Date Deposited: 13 Sep 2009 22:39
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111714 Mental Health @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 100%
Citation Count from Web of Science Web of Science 7
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